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ARHGEF3

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Rho guanine nucleotide exchange factor (GEF) 3, also known as ARHGEF3, is a human gene.^[5]

ARHGEF3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2Z0Q

Identifiers

ARHGEF3, GEF3, STA3, XPLN, Rho guanine nucleotide exchange factor 3

External IDs

OMIM: 612115; MGI: 1918954; HomoloGene: 41329; GeneCards: ARHGEF3; OMA:ARHGEF3 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3p14.3	Start	56,727,418 bp^[1]
Band	3p14.3	End	57,079,329 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	14 A3\|14 16.09 cM	Start	26,836,856 bp^[2]
Band	14 A3\|14 16.09 cM	End	27,125,868 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

glomerulus

metanephric glomerulus

endothelial cell

Epithelium of choroid plexus

Brodmann area 23

germinal epithelium

middle temporal gyrus

granulocyte

oral cavity

parietal pleura

Top expressed in

granulocyte

lobe of cerebellum

pontine nuclei

cerebellar vermis

right lung

right lung lobe

subiculum

deep cerebellar nuclei

olfactory tubercle

lateral septal nucleus

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding guanyl-nucleotide exchange factor activity
Cellular component	cytoplasm cytosol intracellular anatomical structure
Biological process	regulation of Rho protein signal transduction intracellular signal transduction regulation of small GTPase mediated signal transduction Rho protein signal transduction positive regulation of apoptotic process G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO

Species

Human

Mouse


50650


71704


ENSG00000163947


ENSMUSG00000021895


Q9NR81


Q91X46

RefSeq (mRNA)

NM_001128615 NM_001128616 NM_001289698 NM_019555 NM_001377407
NM_001377408 NM_001377409 NM_001377410 NM_001377411 NM_001377412 NM_001377413 NM_001377414 NM_001377415


NM_001289686 NM_001289687 NM_001289688 NM_027871

RefSeq (protein)

NP_001122087 NP_001122088 NP_001276627 NP_062455 NP_001364336
NP_001364337 NP_001364338 NP_001364339 NP_001364340 NP_001364341 NP_001364342 NP_001364343 NP_001364344


NP_001276615 NP_001276616 NP_001276617 NP_082147

Location (UCSC)

Chr 3: 56.73 – 57.08 Mb

Chr 14: 26.84 – 27.13 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to the NET1A protein.^[5]

Interactions

ARHGEF3 has been shown to interact with RHOA^[6] and RHOB.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163947 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021895 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ ^a ^b "Entrez Gene: ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3".

^ ^a ^b Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (Nov 2002). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964–72. doi:10.1074/jbc.M207401200. PMID 12221096.

External links

Human ARHGEF3 genome location and ARHGEF3 gene details page in the UCSC Genome Browser.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.

Thiesen S, Kübart S, Ropers HH, Nothwang HG (2000). "Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22". Biochem. Biophys. Res. Commun. 273 (1): 364–9. doi:10.1006/bbrc.2000.2925. PMID 10873612.

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.

Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (2003). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964–72. doi:10.1074/jbc.M207401200. PMID 12221096.

Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.

Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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