Armadillo repeat containing X-linked 6 is a protein that in humans is encoded by the ARMCX6 gene located on the X-chromosome.[5]
| ARMCX6 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | ARMCX6, GASP10, armadillo repeat containing, X-linked 6, armadillo repeat containing X-linked 6 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 2147993; HomoloGene: 10373; GeneCards: ARMCX6; OMA:ARMCX6 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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It is one of six armadillo repeats containing X-linked proteins (ARMCX1, ARMCX2, ARMCX3, ARMCX4, ARMCX5, and ARMCX6 (this protein)).
The function of this protein is unknown at this time.
1 MGRAREVGWM AAGLMIGAGA CYCVYKLTIG RDDSEKLEEE
41 GEEEWDDDQE LDEEEPDIWF DFETMARPWT EDGDWTEPGA
81 PGGTEDRPSG GGKANRAHPI KQRPFPYEHK NTWSAQNCKN
121 GSCVLDLSKC LFIQGKLLFA EPKDAGFPFS QDINSHLASL
161 SMARNTSPTP DPTVREALCA PDNLNASIES QGQIKMYINE
201 VCRETVSRCC NSFLQQAGLN LLISMTVINN MLAKSASDLK
241 FPLISEGSGC AKVQVLKPLM GLSEKPVLAG ELVGAQMLFS
301 FMSLFIRNGN REILLETPAP
ARMCX6 is conserved in many eukaryotic organisms.
| taxonomic name | common name | NCBI entry | Percentage of sequence similarity | Length (AAs) | comments |
| Homo sapiens | Human | [1] | 100% | 300 | armadillo repeat containing X-linked 6 |
| Macaca mulatta | Rhesus monkey | [2] | 97.0% | 300 | PREDICTED: similar to amrmadillo repeat containing, X-linked 6 (H. sapiens)-like isoform 1 |
| Equus caballus | Horse | [3] | 90.0% | 300 | PREDICTED: similar to armadillo repeat containing, X-linked 6 |
| Danio rerio | zebrafish | [4] | 84.0% | 301 | Similar to RIKEN cDNA 0610039K22 |
| Mus musculus | House Mouse | [5] | 97.7% | 393 | armadillo repeat containing, X-linked 6 (H. sapiens)-like |
| Bos taurus | cow | [6] | 83.0% | 301 | armadillo repeat containing, X-linked 6 |
| Mus musculus | Mouse | [7] | 82.0% | 301 | armadillo repeat containing, X-linked 6 |
| Takifugu rubripes | Tetradontoidea | [8] | 66.0% | 818 | aryl hydrocarbon receptor 2C |
| Caenorhabditis elegans | C. elegans | [9] | 50.0% | 332 | Serpentine Receptor, class H family member (srh-216) |
| Saccharomyces cerevisiae | Yeast | [10] | 70.0% | 910 | Hul5p |
| Gallus gallus | Chicken | [11] | 52.0% | 317 | PREDICTED: hypothetical protein |
The secondary structure of ARMCX6 is predicted to be similar to cyanase. A comparison of the two sequences is shown below.[6][7]
10 20 30 40
....*....|....*....|....*....|....*....|....*..
ARMCX6 231 MLAKSASDLKFPLISEGSGCAKVQVLKPLMGLSEKPVLAGELVGAQM 277
1DW9_A 19 LLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKL 65
+ + ++ + + + + + + + + + + ++++
Microarray data show that ARMCX6 is highly expressed during earliest stages of spermatogenesis in mice.[8][9][10]
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