Charged multivesicular body protein 5 is a protein that in humans is encoded by the CHMP5 gene.[4][5][6]
CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.[6][7]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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