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CSF2RB

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CSF2RB (also known as cytokine receptor common subunit beta) is a common subunit to the following type I cytokine receptors:

GM-CSF receptor

IL-5 receptor.^[5]

CSF2RB

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1C8P, 1EGJ, 1GH7, 2GYS, 4NKQ, 5DWU, 2NA9, 2NA8

Identifiers

CSF2RB, CD131, CDw131, IL3RB, IL5RB, SMDP5, colony stimulating factor 2 receptor beta common subunit, betaGMR, colony stimulating factor 2 receptor subunit beta

External IDs

OMIM: 138981; MGI: 1339760; HomoloGene: 339; GeneCards: CSF2RB; OMA:CSF2RB - orthologs

Gene location (Human)

Chr.	Chromosome 22 (human)^[1]

Band	22q12.3	Start	36,913,628 bp^[1]
Band	22q12.3	End	36,940,439 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	15 E1\|15 37.22 cM	Start	78,166,707 bp^[2]
Band	15 E1\|15 37.22 cM	End	78,189,921 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

blood

periodontal fiber

decidua

appendix

epithelium of nasopharynx

mononuclear cell

monocyte

bone marrow

bone marrow cells

testicle

Top expressed in

mesenteric lymph nodes

granulocyte

stroma of bone marrow

subcutaneous adipose tissue

lactiferous gland

tibiofemoral joint

muscle of thigh

blood

spleen

Paneth cell

More reference expression data

n/a

Gene ontology
Molecular function	interleukin-3 receptor activity interleukin-5 receptor activity protein binding cytokine receptor activity protein tyrosine kinase activity signaling receptor activity
Cellular component	integral component of membrane membrane plasma membrane integral component of plasma membrane granulocyte macrophage colony-stimulating factor receptor complex intracellular anatomical structure
Biological process	respiratory gaseous exchange by respiratory system MAPK cascade signal transduction response to lipopolysaccharide peptidyl-tyrosine phosphorylation interleukin-5-mediated signaling pathway cellular response to interleukin-3 interleukin-3-mediated signaling pathway cytokine-mediated signaling pathway
Sources:Amigo / QuickGO

Species

Human

Mouse


1439


12984


ENSG00000100368


ENSMUSG00000071714


P32927


P26954

RefSeq (mRNA)


NM_000395


NM_001287389 NM_007781

RefSeq (protein)


NP_000386


NP_001274318 NP_031807

Location (UCSC)

Chr 22: 36.91 – 36.94 Mb

Chr 15: 78.17 – 78.19 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100368 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071714 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF (November 1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". The EMBO Journal. 13 (21): 5176–85. doi:10.1002/j.1460-2075.1994.tb06848.x. PMC 395466. PMID 7957082.

External links

Cytokine+Receptor+Common+beta+Subunit at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: P32927 (Human Cytokine receptor common subunit beta (CSF2RB)) at the PDBe-KB.

Retrieved from "https://en.wikipedia.org/w/index.php?title=CSF2RB&oldid=1086554816" Last edited on 6 May 2022, at 21:47

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