This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection.[6] This protein may also play a role in sensing virally derived cytosolic nucleic acids.[7] Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells.[8]
DHX29 has been shown to interact with the eukaryotic small ribosomal subunit (40S) and eIF3.[9][10][11][12]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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