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EIF1AY

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Eukaryotic translation initiation factor 1A, Y-chromosomal is a protein that in humans is encoded by the EIF1AY gene.^[5]^[6]

EIF1AY

Identifiers

EIF1AY, eIF-4C, eukaryotic translation initiation factor 1A, Y-linked, eukaryotic translation initiation factor 1A Y-linked

External IDs

OMIM: 400014; MGI: 1913485; HomoloGene: 100715; GeneCards: EIF1AY; OMA:EIF1AY - orthologs

Gene location (Human)

Chr.	Y chromosome (human)^[1]

Band	Yq11.223	Start	20,575,776 bp^[1]
Band	Yq11.223	End	20,593,154 bp^[1]

Gene location (Mouse)

Chr.	X chromosome (mouse)^[2]

Band	X\|X F4	Start	158,155,174 bp^[2]
Band	X\|X F4	End	158,172,924 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

trabecular bone

vena cava

apex of heart

gonad

rectum

mucosa of transverse colon

right lung

testicle

tendon of biceps brachii

seminal vesicula

Top expressed in

otic placode

saccule

otic vesicle

primitive streak

hair follicle

superior cervical ganglion

medial ganglionic eminence

maxillary prominence

endothelial cell of lymphatic vessel

mandibular prominence

More reference expression data


More reference expression data

Species

Human

Mouse


9086


66235


ENSG00000198692


ENSMUSG00000067194


O14602


Q8BMJ3

RefSeq (mRNA)


NM_004681 NM_001278612


NM_025437

RefSeq (protein)


NP_001265541 NP_004672


NP_079713

Location (UCSC)

Chr Y: 20.58 – 20.59 Mb

Chr X: 158.16 – 158.17 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Like its X-chromosomal counterpart EIF1AX, it encodes an isoform of eukaryotic translation initiation factor 1A (EIF1A). EIF1A is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. It has one amino acid difference (M50L) from EIF1AX.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198692 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067194 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Lahn BT, Page DC (Nov 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.

^ ^a ^b "Entrez Gene: EIF1AY eukaryotic translation initiation factor 1A, Y-linked".

Further reading

Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution". PLOS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450.

Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Mol. Biol. Evol. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.

Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. Bibcode:2003Natur.423..825S. doi:10.1038/nature01722. PMID 12815422.

Marintchev A, Kolupaeva VG, Pestova TV, Wagner G (2003). "Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: A new interaction between old partners". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1535–40. Bibcode:2003PNAS..100.1535M. doi:10.1073/pnas.0437845100. PMC 149867. PMID 12569173.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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