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Electroneutral sodium bicarbonate exchanger 1

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Electroneutral sodium bicarbonate exchanger 1 is a protein that in humans is encoded by the SLC4A8 gene.^[5]^[6]

SLC4A8

Identifiers

SLC4A8, NBC3, NDCBE, solute carrier family 4 member 8

External IDs

OMIM: 605024; MGI: 1928745; HomoloGene: 68419; GeneCards: SLC4A8; OMA:SLC4A8 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q13.13	Start	51,391,317 bp^[1]
Band	12q13.13	End	51,515,763 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	15\|15 F1	Start	100,659,628 bp^[2]
Band	15\|15 F1	End	100,721,849 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

pons

Brodmann area 23

superior vestibular nucleus

corpus callosum

middle temporal gyrus

ventral tegmental area

postcentral gyrus

inferior ganglion of vagus nerve

lateral nuclear group of thalamus

cerebellar vermis

Top expressed in

spermatocyte

spermatid

zygote

neural layer of retina

secondary oocyte

lumbar subsegment of spinal cord

superior frontal gyrus

dentate gyrus of hippocampal formation granule cell

primary oocyte

cerebellar cortex

More reference expression data


More reference expression data

Gene ontology
Molecular function	antiporter activity inorganic anion exchanger activity anion transmembrane transporter activity sodium:bicarbonate symporter activity
Cellular component	integral component of membrane neuronal cell body membrane neuron projection plasma membrane membrane integral component of plasma membrane
Biological process	anion transport sodium ion transport regulation of intracellular pH inorganic anion transport ion transport bicarbonate transport transmembrane transport anion transmembrane transport
Sources:Amigo / QuickGO

Species

Human

Mouse


9498


59033


ENSG00000050438


ENSMUSG00000023032


Q2Y0W8


Q8JZR6

RefSeq (mRNA)

NM_001039960 NM_001258401 NM_001258402 NM_001258403 NM_001267615
NM_004858 NM_001405266 NM_001405268 NM_001405270


NM_001033218 NM_021530 NM_001347102

RefSeq (protein)


NP_001035049 NP_001245330 NP_001245331 NP_001245332 NP_001254544


NP_001334031 NP_067505

Location (UCSC)

Chr 12: 51.39 – 51.52 Mb

Chr 15: 100.66 – 100.72 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

See also

Interactions

SLC4A8 has been shown to interact with Sodium-hydrogen antiporter 3 regulator 1^[7]^[8] and Cystic fibrosis transmembrane conductance regulator.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000050438 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023032 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Grichtchenko II, Choi I, Zhong X, Bray-Ward P, Russell JM, Boron WF (May 2001). "Cloning, characterization, and chromosomal mapping of a human electroneutral Na⁺-driven Cl⁻HCO₃ exchanger". J Biol Chem. 276 (11): 8358–63. doi:10.1074/jbc.C000716200. PMID 11133997.

^ "Entrez Gene: SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8".

^ Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I (March 2003). "The COOH termini of NBC3 and the 56-kDa H⁺-ATPase subunit are PDZ motifs involved in their interaction". Am. J. Physiol., Cell Physiol. 284 (3): C667–73. doi:10.1152/ajpcell.00225.2002. PMID 12444018. S2CID 7070088.

^ ^a ^b Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I (December 2002). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO₃⁻ salvage transporter human Na⁺-HCO₃⁻ cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779.

Further reading

Soleimani M (2002). "Na⁺:HCO₃⁻ cs (NBC): expression and regulation in the kidney". J. Nephrol. 15 (Suppl 5): S32–40. PMID 12027220.

Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Loiselle FB, Morgan PE, Alvarez BV, Casey JR (2004). "Regulation of the human NBC3 Na⁺/HCO₃⁻ cotransporter by carbonic anhydrase II and PKA". Am. J. Physiol., Cell Physiol. 286 (6): C1423–33. doi:10.1152/ajpcell.00382.2003. PMID 14736710.

Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I (2003). "The COOH termini of NBC3 and the 56-kDa H⁺-ATPase subunit are PDZ motifs involved in their interaction". Am. J. Physiol., Cell Physiol. 284 (3): C667–73. doi:10.1152/ajpcell.00225.2002. PMID 12444018. S2CID 7070088.

Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I (2003). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO₃⁻ salvage transporter human Na⁺-HCO₃⁻ cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779.

Gresz V, Kwon TH, Vorum H, Zelles T, Kurtz I, Steward MC, Aalkjaer C, Nielsen S (2002). "Immunolocalization of electroneutral Na⁺-HCO cotransporters in human and rat salivary glands". Am. J. Physiol. Gastrointest. Liver Physiol. 283 (2): G473–80. doi:10.1152/ajpgi.00421.2001. PMID 12121896.

Amlal H, Burnham CE, Soleimani M (1999). "Characterization of Na⁺/HCO₃⁻ cotransporter isoform NBC-3". Am. J. Physiol. 276 (6 Pt 2): F903–13. doi:10.1152/ajprenal.1999.276.6.F903. PMID 10362779.

Pushkin A, Abuladze N, Lee I, Newman D, Hwang J, Kurtz I (1999). "Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family". J. Biol. Chem. 274 (23): 16569–75. doi:10.1074/jbc.274.23.16569. PMID 10347222.

Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.

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