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GSG2

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Serine/threonine-protein kinase haspin is an enzyme that in humans is encoded by the GSG2 gene.^[5]

HASPIN

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2VUW, 2WB8, 3DLZ, 3E7V, 3F2N, 3FMD, 3IQ7, 4OUC, 4QTC, 5HTC, 5HTB

Identifiers

HASPIN, GSG2, germ cell associated 2, haspin, histone H3 associated protein kinase

External IDs

OMIM: 609240; MGI: 1194498; HomoloGene: 49236; GeneCards: HASPIN; OMA:HASPIN - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17p13.2	Start	3,723,903 bp^[1]
Band	17p13.2	End	3,726,699 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11 B4\|11 45.25 cM	Start	73,026,311 bp^[2]
Band	11 B4\|11 45.25 cM	End	73,029,120 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

pancreatic ductal cell

secondary oocyte

ventricular zone

testicle

tibialis anterior muscle

ganglionic eminence

bone marrow cells

sperm

mucosa of ileum

stromal cell of endometrium

Top expressed in

spermatid

seminiferous tubule

spermatocyte

zygote

primary oocyte

secondary oocyte

tail of embryo

genital tubercle

primitive streak

epiblast

More reference expression data

n/a

Gene ontology
Molecular function	transferase activity nucleotide binding kinase activity protein serine/threonine kinase activity protein binding histone kinase activity (H3-T3 specific) ATP binding protein kinase activity
Cellular component	cytoplasm centrosome chromosome cytoskeleton nucleus spindle
Biological process	intracellular signal transduction phosphorylation mitotic sister chromatid cohesion protein localization to chromosome, centromeric region cell cycle protein phosphorylation chromatin organization mitotic cell cycle
Sources:Amigo / QuickGO

Species

Human

Mouse


83903


14841


ENSG00000177602


ENSMUSG00000050107


Q8TF76


Q9Z0R0

RefSeq (mRNA)


NM_031965


NM_010353

RefSeq (protein)


NP_114171


NP_034483

Location (UCSC)

Chr 17: 3.72 – 3.73 Mb

Chr 11: 73.03 – 73.03 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177602 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050107 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Entrez Gene: GSG2 germ cell associated 2 (haspin)".

Further reading

Dai J, Sullivan BA, Higgins JM (2007). "Regulation of mitotic chromosome cohesion by Haspin and Aurora B." Dev. Cell. 11 (5): 741–50. doi:10.1016/j.devcel.2006.09.018. PMID 17084365.

Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.

Dai J, Sultan S, Taylor SS, Higgins JM (2005). "The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment". Genes Dev. 19 (4): 472–88. doi:10.1101/gad.1267105. PMC 548948. PMID 15681610.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Higgins JM (2001). "The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as well as haploid cells". Gene. 267 (1): 55–69. doi:10.1016/S0378-1119(01)00387-0. PMID 11311556.

Tanaka H, Iguchi N, Nakamura Y, et al. (2001). "Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase". Mol. Hum. Reprod. 7 (3): 211–8. doi:10.1093/molehr/7.3.211. PMID 11228240.

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