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KCNG4

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Potassium voltage-gated channel subfamily G member 4 is a protein that in humans is encoded by the KCNG4 gene.^[5]^[6] The protein encoded by this gene is a voltage-gated potassium channel subunit.^[6]

KCNG4

Identifiers

KCNG4, KV6.3, KV6.4, potassium voltage-gated channel modifier subfamily G member 4

External IDs

OMIM: 607603; MGI: 1913983; HomoloGene: 23553; GeneCards: KCNG4; OMA:KCNG4 - orthologs

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16q24.1	Start	84,218,657 bp^[1]
Band	16q24.1	End	84,240,012 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 E1	Start	120,350,593 bp^[2]
Band	8\|8 E1	End	120,362,419 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

testicle

amygdala

substantia nigra

hypothalamus

C1 segment

prefrontal cortex

hippocampus proper

putamen

anterior cingulate cortex

nucleus accumbens

Top expressed in

facial motor nucleus

cerebellar cortex

knee joint

lumbar subsegment of spinal cord

vastus lateralis muscle

habenula

triceps brachii muscle

temporal muscle

cerebellar vermis

deep cerebellar nuclei

More reference expression data

n/a

Gene ontology
Molecular function	voltage-gated potassium channel activity ion channel activity potassium channel activity delayed rectifier potassium channel activity transmembrane transporter binding voltage-gated ion channel activity
Cellular component	integral component of membrane voltage-gated potassium channel complex plasma membrane membrane
Biological process	potassium ion transport regulation of ion transmembrane transport protein homooligomerization ion transport transmembrane transport potassium ion transmembrane transport
Sources:Amigo / QuickGO

Species

Human

Mouse


93107


66733


ENSG00000168418


ENSMUSG00000045246


Q8TDN1


Q80XM3

RefSeq (mRNA)


NM_172347 NM_133490


NM_025734 NM_001357210

RefSeq (protein)


NP_758857


NP_080010 NP_001344139

Location (UCSC)

Chr 16: 84.22 – 84.24 Mb

Chr 8: 120.35 – 120.36 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168418 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045246 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ (Jun 2002). "Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome". Proc Natl Acad Sci U S A. 99 (12): 7986–91. Bibcode:2002PNAS...99.7986O. doi:10.1073/pnas.122617999. PMC 123007. PMID 12060745.

^ ^a ^b Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

Further reading

Mederos Y, Schnitzler M, Rinné S, Skrobek L, et al. (2009). "Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4". J. Biol. Chem. 284 (7): 4695–704. doi:10.1074/jbc.M808786200. PMID 19074135.

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Ottschytsch N, Raes AL, Timmermans JP, Snyders DJ (2005). "Domain analysis of Kv6.3, an electrically silent channel". J. Physiol. 568 (Pt 3): 737–47. doi:10.1113/jphysiol.2005.090142. PMC 1464172. PMID 16096342.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

Kv6.4+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
KCNG4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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Retrieved from "https://en.wikipedia.org/w/index.php?title=KCNG4&oldid=1118753155" Last edited on 28 October 2022, at 17:36

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