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KCNJ13

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Potassium inwardly-rectifying channel, subfamily J, member 13 (KCNJ13) is a human gene encoding the K_ir7.1 protein.^[5]

KCNJ13

Identifiers

KCNJ13, KIR1.4, KIR7.1, LCA16, SVD, potassium voltage-gated channel subfamily J member 13, potassium inwardly rectifying channel subfamily J member 13

External IDs

OMIM: 603208; MGI: 3781032; HomoloGene: 55638; GeneCards: KCNJ13; OMA:KCNJ13 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q37.1	Start	232,765,802 bp^[1]
Band	2q37.1	End	232,776,565 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1 D\|1	Start	87,314,085 bp^[2]
Band	1 D\|1	End	87,322,451 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

Epithelium of choroid plexus

retinal pigment epithelium

jejunal mucosa

testicle

buccal mucosa cell

sural nerve

mucosa of ileum

Achilles tendon

duodenum

bone marrow cells

Top expressed in

Epithelium of choroid plexus

retinal pigment epithelium

iris

otolith organ

utricle

ciliary body

sciatic nerve

olfactory epithelium

stria vascularis

vestibular membrane of cochlear duct

More reference expression data


More reference expression data

Gene ontology
Molecular function	inward rectifier potassium channel activity voltage-gated ion channel activity
Cellular component	integral component of membrane integral component of plasma membrane membrane
Biological process	potassium ion transport regulation of ion transmembrane transport ion transport potassium ion import across plasma membrane
Sources:Amigo / QuickGO

Species

Human

Mouse


3769


100040591


ENSG00000115474


ENSMUSG00000079436


O60928


P86046

RefSeq (mRNA)


NM_002242 NM_001172416 NM_001172417


NM_001110227

RefSeq (protein)


NP_001165887 NP_001165888 NP_002233


NP_001103697

Location (UCSC)

Chr 2: 232.77 – 232.78 Mb

Chr 1: 87.31 – 87.32 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

See also

Inward-rectifier potassium ion channel

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115474 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000079436 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Entrez Gene: KCNJ13 potassium inwardly-rectifying channel, subfamily J, member 13".

Further reading

Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (December 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.

Krapivinsky G, Medina I, Eng L, Krapivinsky L, Yang Y, Clapham DE (May 1998). "A novel inward rectifier K+ channel with unique pore properties". Neuron. 20 (5): 995–1005. doi:10.1016/S0896-6273(00)80480-8. PMID 9620703. S2CID 16356235.

Partiseti M, Collura V, Agnel M, Culouscou JM, Graham D (August 1998). "Cloning and characterization of a novel human inwardly rectifying potassium channel predominantly expressed in small intestine". FEBS Letters. 434 (1–2): 171–6. Bibcode:1998FEBSL.434..171P. doi:10.1016/S0014-5793(98)00972-7. PMID 9738472. S2CID 27138272.

Döring F, Derst C, Wischmeyer E, Karschin C, Schneggenburger R, Daut J, Karschin A (November 1998). "The epithelial inward rectifier channel Kir7.1 displays unusual K+ permeation properties". The Journal of Neuroscience. 18 (21): 8625–36. doi:10.1523/JNEUROSCI.18-21-08625.1998. PMC 6793533. PMID 9786970.

Derst C, Döring F, Preisig-Müller R, Daut J, Karschin A, Jeck N, Weber S, Engel H, Grzeschik KH (December 1998). "Partial gene structure and assignment to chromosome 2q37 of the human inwardly rectifying K+ channel (Kir7.1) gene (KCNJ13)". Genomics. 54 (3): 560–3. doi:10.1006/geno.1998.5598. PMID 9878260.

Nakamura N, Suzuki Y, Sakuta H, Ookata K, Kawahara K, Hirose S (September 1999). "Inwardly rectifying K+ channel Kir7.1 is highly expressed in thyroid follicular cells, intestinal epithelial cells and choroid plexus epithelial cells: implication for a functional coupling with Na+,K+-ATPase". The Biochemical Journal. 342 ( Pt 2) (2): 329–36. doi:10.1042/0264-6021:3420329. PMC 1220469. PMID 10455019.

Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

KCNJ13+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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Retrieved from "https://en.wikipedia.org/w/index.php?title=KCNJ13&oldid=1234935078" Last edited on 16 July 2024, at 22:10

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