Programmed cell death protein 4 is a protein that in humans is encoded by the PDCD4 gene.[5][6] It is one of the targets of an oncomiR, MIRN21.[7]
This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.[6]
PDCD4 has been shown to interact with RPS13,[8] ribosomal protein L5, [8] p62, LC3 and Ubiquitin [9]
9. Manirujjaman M, Ozaki I, Murata Y, Guo J, Xia J, Nishioka K, Perveen R,Takahashi H, Anzai K, Matsuhashi S (2020). "Degradation of the Tumor Suppressor PDCD4 Is Impaired by the Suppression of p62/SQSTM1 and Autophagy". Cells. 9(1): 218. doi.org/10.3390/cells9010218.
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