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PTPN13

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Tyrosine-protein phosphatase non-receptor type 13 is an enzyme that in humans is encoded by the PTPN13 gene.^[5]^[6]

PTPN13

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1D5G, 1Q7X, 1WCH, 2M0Z, 2M10, 3LNX, 3LNY, 3PDZ

Identifiers

Aliases

PTPN13, FAP-1, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE, hPTP1E, protein tyrosine phosphatase, non-receptor type 13, protein tyrosine phosphatase non-receptor type 13

External IDs

OMIM: 600267; MGI: 103293; HomoloGene: 7909; GeneCards: PTPN13; OMA:PTPN13 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q21.3	Start	86,594,315 bp^[1]
Band	4q21.3	End	86,815,171 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5 E5\|5 50.43 cM	Start	103,573,058 bp^[2]
Band	5 E5\|5 50.43 cM	End	103,746,169 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

mucosa of paranasal sinus

urethra

human penis

palpebral conjunctiva

retinal pigment epithelium

skin of arm

renal medulla

trigeminal ganglion

gingival epithelium

mucosa of pharynx

Top expressed in

corneal stroma

hair follicle

mucosa of urinary bladder

transitional epithelium of urinary bladder

retinal pigment epithelium

medullary collecting duct

skin of external ear

conjunctival fornix

skin of back

sciatic nerve

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein tyrosine phosphatase activity phosphatase activity phosphatidylinositol 3-kinase regulatory subunit binding protein binding phosphoprotein phosphatase activity hydrolase activity
Cellular component	cytoplasm cell body neuron projection cell projection extracellular exosome cytoskeleton nucleus lamellipodium plasma membrane nucleoplasm
Biological process	protein dephosphorylation peptidyl-tyrosine dephosphorylation regulation of phosphatidylinositol 3-kinase signaling dephosphorylation phosphatidylinositol biosynthetic process negative regulation of protein phosphorylation cellular response to cytokine stimulus bicellular tight junction assembly
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5783


19249

Ensembl


ENSG00000163629


ENSMUSG00000034573

UniProt


Q12923


Q64512

RefSeq (mRNA)


NM_006264 NM_080683 NM_080684 NM_080685


NM_011204

RefSeq (protein)


NP_006255 NP_542414 NP_542415 NP_542416


NP_035334

Location (UCSC)

Chr 4: 86.59 – 86.82 Mb

Chr 5: 103.57 – 103.75 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as IkappaBalpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.^[6]

Interactions

edit

PTPN13 has been shown to interact with PKN2.^[7]

References

edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163629 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034573 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Maekawa K, Imagawa N, Nagamatsu M, Harada S (Feb 1994). "Molecular cloning of a novel protein-tyrosine phosphatase containing a membrane-binding domain and GLGF repeats". FEBS Lett. 337 (2): 200–206. doi:10.1016/0014-5793(94)80273-4. PMID 8287977. S2CID 46269697.

^ ^a ^b "Entrez Gene: PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)".

^ Gross C, Heumann R, Erdmann K S (May 2001). "The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif". FEBS Lett. 496 (2–3): 101–104. doi:10.1016/S0014-5793(01)02401-2. ISSN 0014-5793. PMID 11356191. S2CID 205880882.

Yanagisawa J, Takahashi M, Kanki H, Yano-Yanagisawa H, Tazunoki T, Sawa E, Nishitoba T, Kamishohara M, Kobayashi E (1997). "The molecular interaction of Fas and FAP-1. A tripeptide blocker of human Fas interaction with FAP-1 promotes Fas-induced apoptosis". J. Biol. Chem. 272 (13): 8539–8545. doi:10.1074/jbc.272.13.8539. PMID 9079683.

Saras J, Engström U, Góñez LJ, Heldin CH (1997). "Characterization of the interactions between PDZ domains of the protein-tyrosine phosphatase PTPL1 and the carboxyl-terminal tail of Fas". J. Biol. Chem. 272 (34): 20979–20981. doi:10.1074/jbc.272.34.20979. PMID 9261095.

Saras J, Franzén P, Aspenström P, Hellman U, Gonez LJ, Heldin CH (1997). "A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1". J. Biol. Chem. 272 (39): 24333–24338. doi:10.1074/jbc.272.39.24333. PMID 9305890.

Ekiel I, Banville D, Shen SH, Slon-Usakiewicz JJ, Koshy A, Gehring K (1999). "Main-chain signal assignment for the PDZ2 domain from human protein tyrosine phosphatase hPTP1E and its complex with a C-terminal peptide from the Fas receptor". J. Biomol. NMR. 12 (3): 455–456. doi:10.1023/A:1008267807859. PMID 9835052. S2CID 19976473.

Maekawa K, Imagawa N, Naito A, Harada S, Yoshie O, Takagi S (1999). "Association of protein-tyrosine phosphatase PTP-BAS with the transcription-factor-inhibitory protein IkappaBalpha through interaction between the PDZ1 domain and ankyrin repeats". Biochem. J. 337 (2): 179–84. doi:10.1042/0264-6021:3370179. PMC 1219950. PMID 9882613.

Lin D, Gish GD, Songyang Z, Pawson T (1999). "The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif". J. Biol. Chem. 274 (6): 3726–3733. doi:10.1074/jbc.274.6.3726. PMID 9920925.

Murthy KK, Clark K, Fortin Y, Shen SH, Banville D (1999). "ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E". J. Biol. Chem. 274 (29): 20679–20687. doi:10.1074/jbc.274.29.20679. PMID 10400701.

Cuppen E, van Ham M, Pepers B, Wieringa B, Hendriks W (1999). "Identification and molecular characterization of BP75, a novel bromodomain-containing protein". FEBS Lett. 459 (3): 291–298. doi:10.1016/S0014-5793(99)01191-6. PMID 10526152. S2CID 41216030.

Irie S, Hachiya T, Rabizadeh S, Maruyama W, Mukai J, Li Y, Reed JC, Bredesen DE, Sato TA (1999). "Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation". FEBS Lett. 460 (2): 191–198. doi:10.1016/S0014-5793(99)01324-1. PMID 10544233. S2CID 25143664.

Lee SH, Shin MS, Park WS, Kim SY, Kim HS, Lee JH, Han SY, Lee HK, Park JY (2000). "Immunohistochemical localization of FAP-1, an inhibitor of Fas-mediated apoptosis, in normal and neoplastic human tissues". APMIS. 107 (12): 1101–1108. doi:10.1111/j.1699-0463.1999.tb01515.x. PMID 10660140. S2CID 24672576.

Kozlov G, Gehring K, Ekiel I (2000). "Solution structure of the PDZ2 domain from human phosphatase hPTP1E and its interactions with C-terminal peptides from the Fas receptor". Biochemistry. 39 (10): 2572–2580. doi:10.1021/bi991913c. PMID 10704206.

Cuppen E, van Ham M, Wansink DG, De Leeuw A, Wieringa B, Hendriks W (2000). "The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL". Eur. J. Cell Biol. 79 (4): 283–293. doi:10.1078/S0171-9335(04)70031-X. PMID 10826496.

Erdmann KS, Kuhlmann J, Lessmann V, Herrmann L, Eulenburg V, Müller O, Heumann R (2000). "The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain". Oncogene. 19 (34): 3894–3901. doi:10.1038/sj.onc.1203725. PMID 10951583.

Nakai Y, Irie S, Sato TA (2001). "Identification of IkappaBalpha as a substrate of Fas-associated phosphatase-1". Eur. J. Biochem. 267 (24): 7170–7175. doi:10.1046/j.1432-1327.2000.01818.x. PMID 11106428.

Gross C, Heumann R, Erdmann KS (2001). "The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif". FEBS Lett. 496 (2–3): 101–104. doi:10.1016/S0014-5793(01)02401-2. PMID 11356191. S2CID 205880882.

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PTPN13

Interactions

References

Further reading

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