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RABGAP1

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RAB GTPase activating protein 1 is a protein in humans that is encoded by the RABGAP1 gene.^[5]

RABGAP1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4NC6

Identifiers

RABGAP1, GAPCENA, TBC1D11, RAB GTPase activating protein 1

External IDs

OMIM: 615882; MGI: 2385139; HomoloGene: 49301; GeneCards: RABGAP1; OMA:RABGAP1 - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9q33.2-q33.3	Start	122,940,833 bp^[1]
Band	9q33.2-q33.3	End	123,104,866 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 B	Start	37,333,291 bp^[2]
Band	2\|2 B	End	37,456,466 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

middle temporal gyrus

olfactory bulb

internal globus pallidus

optic nerve

amniotic fluid

endothelial cell

tail of epididymis

Brodmann area 23

saphenous vein

Top expressed in

genital tubercle

tail of embryo

pineal gland

zygote

superior cervical ganglion

arcuate nucleus

paraventricular nucleus of hypothalamus

median eminence

dorsomedial hypothalamic nucleus

medullary collecting duct

More reference expression data

n/a

Gene ontology
Molecular function	tubulin binding protein binding GTPase activator activity
Cellular component	cytoplasm cytosol centrosome cytoskeleton microtubule associated complex microtubule organizing center endomembrane system
Biological process	regulation of cilium assembly cell cycle positive regulation of GTPase activity activation of GTPase activity regulation of vesicle fusion intracellular protein transport regulation of GTPase activity
Sources:Amigo / QuickGO

Species

Human

Mouse


23637


227800


ENSG00000011454


ENSMUSG00000035437


Q9Y3P9


A2AWA9

RefSeq (mRNA)


NM_012197


NM_001033960 NM_146121 NM_001362956 NM_001362957 NM_001362958

RefSeq (protein)


NP_036329


NP_001029132 NP_666233 NP_001349885 NP_001349886 NP_001349887

Location (UCSC)

Chr 9: 122.94 – 123.1 Mb

Chr 2: 37.33 – 37.46 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000011454 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035437 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Entrez Gene: RAB GTPase activating protein 1".

Further reading

Caratù G, Allegra D, Bimonte M, Schiattarella GG, D'Ambrosio C, Scaloni A, Napolitano M, Russo T, Zambrano N (February 2007). "Identification of the ligands of protein interaction domains through a functional approach". Molecular & Cellular Proteomics. 6 (2): 333–45. doi:10.1074/mcp.M600289-MCP200. PMID 17124247.

Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (November 2000). "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms". Molecular Biology of the Cell. 11 (11): 3819–33. doi:10.1091/mbc.11.11.3819. PMC 15039. PMID 11071909.

Ishibashi K, Kanno E, Itoh T, Fukuda M (January 2009). "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity". Genes to Cells. 14 (1): 41–52. doi:10.1111/j.1365-2443.2008.01251.x. PMID 19077034. S2CID 26454981.

Opdam FJ, Echard A, Croes HJ, van den Hurk JA, van de Vorstenbosch RA, Ginsel LA, Goud B, Fransen JA (August 2000). "The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus". Journal of Cell Science. 113 ( Pt 15) (15): 2725–35. doi:10.1242/jcs.113.15.2725. PMID 10893188.

Cuif MH, Possmayer F, Zander H, Bordes N, Jollivet F, Couedel-Courteille A, Janoueix-Lerosey I, Langsley G, Bornens M, Goud B (April 1999). "Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome". The EMBO Journal. 18 (7): 1772–82. doi:10.1093/emboj/18.7.1772. PMC 1171263. PMID 10202141.

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Retrieved from "https://en.wikipedia.org/w/index.php?title=RABGAP1&oldid=1115896646" Last edited on 13 October 2022, at 19:35

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