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SLITRK2

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SLIT and NTRK-like protein 2 is a protein that in humans is encoded by the SLITRK2 gene.^[5]^[6]^[7]

SLITRK2

Identifiers

SLITRK2, CXorf2, SLITL1, SLIT and NTRK like family member 2, CXorf1, TMEM257

External IDs

OMIM: 300561; MGI: 2679449; HomoloGene: 13054; GeneCards: SLITRK2; OMA:SLITRK2 - orthologs

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	Xq27.3	Start	145,817,829 bp^[1]
Band	Xq27.3	End	145,829,856 bp^[1]

Gene location (Mouse)

Chr.	X chromosome (mouse)^[2]

Band	X\|X A7.1	Start	65,692,924 bp^[2]
Band	X\|X A7.1	End	65,704,999 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

ventricular zone

internal globus pallidus

caudate nucleus

nucleus accumbens

ganglionic eminence

middle temporal gyrus

amygdala

right frontal lobe

putamen

C1 segment

Top expressed in

trigeminal ganglion

substantia nigra

lumbar subsegment of spinal cord

Region I of hippocampus proper

dentate gyrus

dentate gyrus of hippocampal formation granule cell

subiculum

ventricular zone

neural layer of retina

primary motor cortex

More reference expression data


More reference expression data

Species

Human

Mouse


84631


245450


ENSG00000185985


ENSMUSG00000036790


Q9H156


Q810C0

RefSeq (mRNA)

NM_001144003 NM_001144004 NM_001144005 NM_001144006 NM_001144007
NM_001144008 NM_001144009 NM_001144010 NM_032539


NM_001161431 NM_198863

RefSeq (protein)

NP_001137475 NP_001137476 NP_001137477 NP_001137478 NP_001137480
NP_001137481 NP_001137482 NP_115928


NP_001154903 NP_942563

Location (UCSC)

Chr X: 145.82 – 145.83 Mb

Chr X: 65.69 – 65.7 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Function

Members of the SLITRK family, such as SLITRK2, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK2, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity.^[7]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185985 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036790 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (April 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.

^ ^a ^b Aruga J, Yokota N, Mikoshiba K (October 2003). "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue". Gene. 315: 87–94. doi:10.1016/S0378-1119(03)00715-7. PMID 14557068.

^ ^a ^b "Entrez Gene: SLITRK2 SLIT and NTRK-like family, member 2".

Further reading

Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

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Retrieved from "https://en.wikipedia.org/w/index.php?title=SLITRK2&oldid=1079532285" Last edited on 27 March 2022, at 08:27

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