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SPATA5

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Spermatogenesis-associated protein 5 is a protein that in humans is encoded by the SPATA5 gene.^[5]^[6]

SPATA5

Identifiers

SPATA5, AFG2, SPAF, EHLMRS, spermatogenesis associated 5, NEDHSB

External IDs

OMIM: 613940; MGI: 1927170; HomoloGene: 56920; GeneCards: SPATA5; OMA:SPATA5 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q28.1	Start	122,923,070 bp^[1]
Band	4q28.1	End	123,319,433 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 B	Start	37,474,045 bp^[2]
Band	3\|3 B	End	37,633,245 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

tendon of biceps brachii

Achilles tendon

palpebral conjunctiva

gonad

testicle

bone marrow cells

ventricular zone

internal globus pallidus

sural nerve

epithelium of colon

Top expressed in

spermatocyte

primitive streak

seminiferous tubule

primary oocyte

spermatid

Gonadal ridge

genital tubercle

tail of embryo

epiblast

motor neuron

More reference expression data


More reference expression data

Gene ontology
Molecular function	nucleotide binding ATP binding ATPase activity hydrolase activity
Cellular component	cytoplasm mitochondrion
Biological process	multicellular organism development cell differentiation brain development spermatogenesis
Sources:Amigo / QuickGO

Species

Human

Mouse


166378


57815


ENSG00000145375


ENSMUSG00000027722


Q8NB90


Q3UMC0

RefSeq (mRNA)


NM_145207 NM_001317799 NM_001345856


NM_001163511 NM_021343 NM_001310473

RefSeq (protein)


NP_001304728 NP_001332785 NP_660208


NP_001156983 NP_001297402 NP_067318

Location (UCSC)

Chr 4: 122.92 – 123.32 Mb

Chr 3: 37.47 – 37.63 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145375 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027722 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Katoh Y, Katoh M (Feb 2006). "FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells". International Journal of Molecular Medicine. 17 (3): 529–32. doi:10.3892/ijmm.17.3.529. PMID 16465403.

^ "Entrez Gene: SPATA5 spermatogenesis associated 5".

Further reading

Liu Y, Black J, Kisiel N, Kulesz-Martin MF (2000). "SPAF, a new AAA-protein specific to early spermatogenesis and malignant conversion". Oncogene. 19 (12): 1579–88. doi:10.1038/sj.onc.1203442. PMID 10734318.

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.

Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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