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TESK2

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Dual specificity testis-specific protein kinase 2 is an enzyme that in humans is encoded by the TESK2 gene.^[5]^[6]

TESK2

Identifiers

TESK2, testis-specific kinase 2, testis associated actin remodelling kinase 2

External IDs

OMIM: 604746; MGI: 2385204; HomoloGene: 5188; GeneCards: TESK2; OMA:TESK2 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p34.1	Start	45,343,883 bp^[1]
Band	1p34.1	End	45,491,163 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 D1	Start	116,578,145 bp^[2]
Band	4\|4 D1	End	116,663,153 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

cartilage tissue

C1 segment

secondary oocyte

skin of abdomen

jejunal mucosa

skin of limb

skin of leg

duodenum

skin of arm

testicle

Top expressed in

granulocyte

spermatid

lobe of prostate

sciatic nerve

utricle

seminiferous tubule

vestibular membrane of cochlear duct

left colon

stria vascularis

jejunum

More reference expression data


More reference expression data

Gene ontology
Molecular function	transferase activity protein kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity nucleotide binding protein binding ATP binding metal ion binding kinase activity protein serine/threonine kinase activity signal transducer activity
Cellular component	nucleoplasm nucleus cytoplasm nuclear body
Biological process	protein phosphorylation peptidyl-tyrosine phosphorylation focal adhesion assembly actin cytoskeleton organization spermatogenesis phosphorylation intracellular signal transduction
Sources:Amigo / QuickGO

Species

Human

Mouse


10420


230661


ENSG00000070759


ENSMUSG00000033985


Q96S53


Q8VCT9

RefSeq (mRNA)


NM_007170 NM_001320800


NM_146151

RefSeq (protein)


NP_001307729 NP_009101


NP_666263

Location (UCSC)

Chr 1: 45.34 – 45.49 Mb

Chr 4: 116.58 – 116.66 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Function

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meiotic stages and/or early stages of spermiogenesis.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000070759 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033985 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Røsok O, Pedeutour F, Ree AH, Aasheim HC (October 1999). "Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis". Genomics. 61 (1): 44–54. doi:10.1006/geno.1999.5922. PMID 10512679.

^ ^a ^b "Entrez Gene: TESK2 testis-specific kinase 2".

Further reading

Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

Toshima JY, Toshima J, Watanabe T, Mizuno K (November 2001). "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1". The Journal of Biological Chemistry. 276 (46): 43471–81. doi:10.1074/jbc.M104620200. PMID 11555644.

Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K (August 2001). "Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells". The Journal of Biological Chemistry. 276 (33): 31449–58. doi:10.1074/jbc.M102988200. PMID 11418599.

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Retrieved from "https://en.wikipedia.org/w/index.php?title=TESK2&oldid=1081657850" Last edited on 8 April 2022, at 20:21

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