● Home ● Random ● Nearby ● Log in ● Settings ● Donate ● About Wikipedia ● Disclaimers

XIRP2

● Article ● Talk ● Language ● Watch ● Edit

Xin actin-binding repeat-containing protein 2 is a protein that in humans is encoded by the XIRP2 gene.^[5]^[6]^[7]^[8]

XIRP2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4F14

Identifiers

XIRP2, CMYA3, xin actin binding repeat containing 2

External IDs

OMIM: 609778; MGI: 2685198; HomoloGene: 19388; GeneCards: XIRP2; OMA:XIRP2 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q24.3	Start	166,888,480 bp^[1]
Band	2q24.3	End	167,259,753 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 C1.3	Start	67,004,178 bp^[2]
Band	2\|2 C1.3	End	67,356,959 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

deltoid muscle

biceps brachii

Skeletal muscle tissue of rectus abdominis

quadriceps femoris muscle

vastus lateralis muscle

tibialis anterior muscle

Skeletal muscle tissue of biceps brachii

myocardium of left ventricle

body of tongue

muscle of thigh

Top expressed in

muscle of thigh

skeletal muscle tissue

ventricle

quadriceps femoris muscle

interventricular septum

left ventricle

zone of skin

esophagus

lip

superior frontal gyrus

More reference expression data

n/a

Gene ontology
Molecular function	alpha-actinin binding actin binding actin filament binding
Cellular component	cell junction Z disc stress fiber focal adhesion filamentous actin
Biological process	heart development cell-cell junction organization cardiac muscle tissue morphogenesis ventricular septum development actin cytoskeleton organization biological process
Sources:Amigo / QuickGO

Species

Human

Mouse


129446


241431


ENSG00000163092


ENSMUSG00000027022


A4UGR9


Q4U4S6

RefSeq (mRNA)


NM_152381 NM_001079810 NM_001199143 NM_001199144 NM_001199145


NM_001024618 NM_001083919

RefSeq (protein)


NP_001073278 NP_001186072 NP_001186073 NP_001186074 NP_689594


NP_001019789 NP_001077388

Location (UCSC)

Chr 2: 166.89 – 167.26 Mb

Chr 2: 67 – 67.36 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163092 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027022 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Huang HT, Brand OM, Mathew M, Ignatiou C, Ewen EP, McCalmon SA, Naya FJ (Dec 2006). "Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein". J Biol Chem. 281 (51): 39370–9. doi:10.1074/jbc.M603244200. PMID 17046827.

^ Sinn HW, Balsamo J, Lilien J, Lin JJ (Aug 2002). "Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development". Dev Dyn. 225 (1): 1–13. doi:10.1002/dvdy.10131. PMID 12203715. S2CID 23393425.

^ Pacholsky D, Vakeel P, Himmel M, Lowe T, Stradal T, Rottner K, Furst DO, van der Ven PF (Oct 2004). "Xin repeats define a novel actin-binding motif". J Cell Sci. 117 (Pt 22): 5257–68. doi:10.1242/jcs.01406. PMID 15454575. S2CID 5643531.

^ "Entrez Gene: CMYA3 cardiomyopathy associated 3".

Further reading

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

Blasi F, Bacchelli E, Carone S, et al. (2006). "SLC25A12 and CMYA3 gene variants are not associated with autism in the IMGSAC multiplex family sample". Eur. J. Hum. Genet. 14 (1): 123–6. doi:10.1038/sj.ejhg.5201444. PMID 16205742.

Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

Pan PW, Li K, Tuggle CK, et al. (2004). "Sequencing, tissue distribution and physical mapping of the porcine homologue of cardiomyopathy associated 3 (CMYA3)". Anim. Genet. 34 (6): 473–4. doi:10.1046/j.0268-9146.2003.01059.x. PMID 14687087.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

t

e

Retrieved from "https://en.wikipedia.org/w/index.php?title=XIRP2&oldid=1199291928" Last edited on 26 January 2024, at 18:07

Languages

●العربية ●Bosanski ●مصرى ●Татарча / tatarça ●Українська

●This page was last edited on 26 January 2024, at 18:07 (UTC). ●Content is available under CC BY-SA 4.0 unless otherwise noted. ●Privacy policy ●About Wikipedia ●Disclaimers ●Contact Wikipedia ●Code of Conduct ●Developers ●Statistics ●Cookie statement ●Terms of Use ●Desktop