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When it comes to ileitis, the majority of cases are caused by an acute, self-limited form of lower right quadrant pain and/or diarrhea. However, other conditions, such as Mycobacterium tuberculosisorvasculitis, can cause chronic, debilitating symptoms that are complicated by hemorrhage, obstructive symptoms, and/or extraintestinal manifestations. Unless symptoms indicate that additional testing is necessary, ileitis linked to spondyloarthropathyornonsteroidal anti-inflammatory drugs is usually subclinical and goes unnoticed.[1]