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Liver failure

Liver failure
Other names	Hepatic insufficiency, liver dysfunction
A person with massive ascites and caput medusae due to cirrhotic liver failure
Specialty	Gastroenterology, hepatology
Symptoms	abdominal inflammation, fluid retention, hyperglycemia, nausea, vomiting, jaundice, acute or chronic fatigue, hyponatremia, hypokalemia, respiratory alkalosis, metabolic acidosis, bilirubinuria, glycosuria, pruritus
Risk factors	Excessive consumption of alcohol, fatty foods; obesity; Type 2 Diabetes; sharing or reusing syringes; having tattoos or body piercings

Liver failure is the inability of the liver to perform its normal synthetic and metabolic functions as part of normal physiology. Two forms are recognised, acute and chronic (cirrhosis).^[1] Recently, a third form of liver failure known as acute-on-chronic liver failure (ACLF) is increasingly being recognized.^[2]

Acute liver failure is defined as "the rapid development of hepatocellular dysfunction, specifically coagulopathy and mental status changes (encephalopathy) in a patient without known prior liver disease".^[3]:1557[4]

The disease process is associated with the development of a coagulopathy of liver aetiology, and clinically apparent altered level of consciousness due to hepatic encephalopathy. Several important measures are immediately necessary when the patient presents for medical attention.^[5] The diagnosis of acute liver failure is based on a physical exam, laboratory findings, patient history, and past medical history to establish mental status changes, coagulopathy, rapidity of onset, and absence of known prior liver disease respectively.^[3]:1557

The exact definition of "rapid" is somewhat questionable, and different sub-divisions exist, which are based on the time from onset of first hepatic symptoms to onset of encephalopathy. One scheme defines "acute hepatic failure" as the development of encephalopathy within 26 weeks of the onset of any hepatic symptoms. This is sub-divided into "fulminant hepatic failure", which requires onset of encephalopathy within 8 weeks, and "subfulminant", which describes onset of encephalopathy after 8 weeks but before 26 weeks.^[6] Another scheme defines "hyperacute" as onset within 7 days, "acute" as onset between 7 and 28 days, and "subacute" as onset between 28 days and 24 weeks.^[3]:1557

Chronic liver failure usually occurs in the context of cirrhosis, itself potentially the result of many possible causes, such as excessive alcohol intake, hepatitis BorC, autoimmune, hereditary and metabolic causes (such as ironorcopper overload, steatohepatitisornon-alcoholic fatty liver disease).^{[citation needed]}

"Acute on chronic liver failure (ACLF)" is said to exist when someone with chronic liver disease develops features of liver failure. A number of underlying causes may precipitate this, such as alcohol misuse or infection. People with ACLF can be critically ill and require intensive care treatment, and occasionally a liver transplant. Mortality with treatment is 50%.^[7]