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ACSM3

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ACSM3

Identifiers

Aliases

ACSM3, SA, SAH, acyl-CoA synthetase medium-chain family member 3, acyl-CoA synthetase medium chain family member 3

External IDs

OMIM: 145505; MGI: 99538; HomoloGene: 74559; GeneCards: ACSM3; OMA:ACSM3 - orthologs

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16p12.3	Start	20,610,243 bp^[1]
Band	16p12.3	End	20,797,581 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 F2	Start	119,360,146 bp^[2]
Band	7\|7 F2	End	119,386,736 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

left ovary

right ovary

right lobe of liver

left uterine tube

body of pancreas

right uterine tube

mucosa of transverse colon

body of uterus

human kidney

body of stomach

Top expressed in

right kidney

left colon

tunica adventitia of aorta

proximal tubule

left lobe of liver

human kidney

mucous cell of stomach

intercostal muscle

pyloric antrum

brown adipose tissue

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding ligase activity catalytic activity ATP binding metal ion binding fatty-acyl-CoA synthase activity fatty acid ligase activity butyrate-CoA ligase activity molecular function
Cellular component	mitochondrion mitochondrial matrix cellular component
Biological process	regulation of blood pressure cholesterol homeostasis metabolism lipid metabolism fatty acid metabolic process fatty acid biosynthetic process acyl-CoA metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6296


20216

Ensembl


ENSG00000005187


ENSMUSG00000030935

UniProt


Q53FZ2


Q3UNX5

RefSeq (mRNA)


NM_005622 NM_202000


NM_016870 NM_212441 NM_212442

RefSeq (protein)


NP_005613 NP_973729


NP_058566 NP_997606 NP_997607

Location (UCSC)

Chr 16: 20.61 – 20.8 Mb

Chr 7: 119.36 – 119.39 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Acyl-coenzyme A synthetase ACSM3, mitochondrial is an enzyme that in humans is encoded by the ACSM3 gene.^[5]^[6]^[7]^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000005187 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030935 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Nabika T, Bonnardeaux A, James M, Julier C, Jeunemaitre X, Corvol P, Lathrop M, Soubrier F (Jan 1995). "Evaluation of the SA locus in human hypertension". Hypertension. 25 (1): 6–13. doi:10.1161/01.hyp.25.1.6. PMID 7843754.

^ Iwai N, Ohmichi N, Hanai K, Nakamura Y, Kinoshita M (Mar 1994). "Human SA gene locus as a candidate locus for essential hypertension". Hypertension. 23 (3): 375–80. doi:10.1161/01.hyp.23.3.375. PMID 7907320.

^ Fujino T, Takei YA, Sone H, Ioka RX, Kamataki A, Magoori K, Takahashi S, Sakai J, Yamamoto TT (Sep 2001). "Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product". The Journal of Biological Chemistry. 276 (38): 35961–6. doi:10.1074/jbc.M106651200. PMID 11470804.

^ "Entrez Gene: ACSM3 acyl-CoA synthetase medium-chain family member 3".

External links[edit]

Human ACSM3 genome location and ACSM3 gene details page in the UCSC Genome Browser.

Further reading[edit]

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

Samani NJ, Whitmore SA, Kaiser MA, Harris J, See CG, Callen DF, Lodwick D (Mar 1994). "Chromosomal assignment of the human SA gene to 16p13.11 and demonstration of its expression in the kidney". Biochemical and Biophysical Research Communications. 199 (2): 862–8. doi:10.1006/bbrc.1994.1308. PMID 8135833.

Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.

Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Sep 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.

Iwai N, Katsuya T, Mannami T, Higaki J, Ogihara T, Kokame K, Ogata J, Baba S (Jan 2002). "Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension". Circulation. 105 (1): 41–7. doi:10.1161/hc0102.101780. PMID 11772874.

Narita I, Saito N, Goto S, Shirasaki A, Morioka Y, Jin S, Omori K, Sakatsume M, Arakawa M, Gejyo F (Nov 2002). "Role of genetic polymorphism in the SA gene on the blood pressure and prognosis of renal function in patients with immunoglobulin A nephropathy". Hypertension Research. 25 (6): 831–6. doi:10.1291/hypres.25.831. PMID 12484505.

Benjafield AV, Iwai N, Ishikawa K, Wang WY, Morris BJ (Aug 2003). "Overweight, but not hypertension, is associated with SAH polymorphisms in Caucasians with essential hypertension". Hypertension Research. 26 (8): 591–5. doi:10.1291/hypres.26.591. PMID 14567496.

Telgmann R, Brand E, Nicaud V, Hagedorn C, Beining K, Schönfelder J, Brink-Spalink V, Schmidt-Petersen K, Matanis T, Vischer P, Nofer JR, Hasenkamp S, Plouin PF, Drouet L, Cambien F, Paul M, Tiret L, Brand-Herrmann SM (Mar 2007). "SAH gene variants are associated with obesity-related hypertension in Caucasians: the PEGASE Study". Journal of Hypertension. 25 (3): 557–64. doi:10.1097/HJH.0b013e3280144779. PMID 17278971. S2CID 39465138.

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