Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene.[5][6][7] ACVR2B is an activin type 2 receptor.
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.[7]
ACVR2B has been shown to interact with ACVR1B[8][9] and SYNJ2BP.[10]
PDB gallery
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1nys: Crystal Structure of Activin A Bound to the ECD of ActRIIB P41
1nyu: Crystal Structure of Activin A Bound to the ECD of ActRIIB
1s4y: Crystal structure of the activin/actrIIb extracellular domain
2h62: Crystal structure of a ternary ligand-receptor complex of BMP-2
2h64: Crystal structure of a ternary ligand-receptor complex of BMP-2
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TGF beta superfamily of ligands |
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TGF beta receptors (Activin, BMP, family) |
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Transducers/SMAD |
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Ligand inhibitors |
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Coreceptors |
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Activity |
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Regulation |
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Classification |
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Kinetics |
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Type I |
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Type II |
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Type III |
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Unsorted |
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