Death-associated protein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene.[5][6]
This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Gene overexpression induces cell apoptosis. It uses multiple polyadenylation sites.[6]
The DAPK2 mRNA may undergo alternative splicing to produce a DAPK3-like encoding transcript.[7]
PDB gallery
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1wmk: Human death-associated kinase DRP-1, mutant S308D d40
1z9x: Human DRP-1 kinase, W305S S308A D40 mutant, crystal form with 3 monomers in the asymmetric unit
1zws: Crystal structure of the catalytic domain of human DRP-1 kinase
2a27: Human DRP-1 kinase, W305S S308A D40 mutant, crystal form with 8 monomers in the asymmetric unit
2a2a: High-resolution crystallographic analysis of the autoinhibited conformation of a human death-associated protein kinase
2cke: HUMAN DEATH-ASSOCIATED DRP-1 KINASE IN COMPLEX WITH INHIBITOR
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This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it. |