Contents

Acyl-coa synthetase medium chain family member 2a

Protein-coding gene in the species Homo sapiens

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ACSM2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VZE, 2WD9, 3B7W, 3C5E, 3DAY, 3EQ6, 3GPC
Identifiers
Aliases	ACSM2A, A-923A4.1, ACSM2, acyl-CoA synthetase medium-chain family member 2A, acyl-CoA synthetase medium chain family member 2A
External IDs	OMIM: 614358; MGI: 2385289; HomoloGene: 70404; GeneCards: ACSM2A; OMA:ACSM2A - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.3 Start 20,451,461 bp[1] End 20,487,669 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F2 Start 119,153,563 bp[2] End 119,199,913 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver renal cortex metanephric glomerulus human kidney testicle gonad sural nerve gastric mucosa superior frontal gyrus Achilles tendon Top expressed in right kidney proximal tubule human kidney primary visual cortex morula muscle of thigh hair follicle zygote superior frontal gyrus renal corpuscle More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding ligase activity catalytic activity ATP binding butyrate-CoA ligase activity metal ion binding fatty-acyl-CoA synthase activity fatty acid ligase activity Cellular component mitochondrion mitochondrial matrix Biological process medium-chain fatty-acyl-CoA metabolic process metabolism glucose homeostasis fatty acid metabolic process lipid metabolism triglyceride homeostasis fatty acid biosynthetic process acyl-CoA metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 123876 233799 Ensembl ENSG00000183747 ENSMUSG00000030945 UniProt Q08AH3 Q8K0L3 RefSeq (mRNA) NM_001010845 NM_001308169 NM_001308172 NM_001308954 NM_001177977 NM_001177978 NM_146197 RefSeq (protein) NP_001295098 NP_001295101 NP_001295883 NP_001171448 NP_001171449 NP_666309 Location (UCSC) Chr 16: 20.45 – 20.49 Mb Chr 7: 119.15 – 119.2 Mb PubMed search [3] [4]
Wikidata
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Acyl-CoA synthetase medium chain family member 2A is a protein that in humans is encoded by the ACSM2A gene. ^[5]

Function[edit]

This gene encodes a mitochondrial acyl-coenzyme A synthetase that is specific for medium chain fatty acids. These enzymes catalyze fatty acid activation, the first step of fatty acid metabolism, through the transfer of acyl-CoA. These enzymes also participate in the glycine conjugation pathway in the detoxification of xenobiotics such as benzoate and ibuprofen. Expression levels of this gene in the kidney may be correlated with kidney function. This gene and its paralog ACSM2B (Gene ID: 348158), both present on chromosome 16, likely arose from a chromosomal duplication event. [provided by RefSeq, May 2017].

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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