Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.[5]
The CRK protein participates in the Reelin signaling cascade downstream of DAB1.[6][7]
Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. This protein has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.[8]
Crk together with CrkL participates in the Reelin signaling cascade downstream of DAB1.[6][7]
v-Crk, a transforming oncoprotein from avian sarcoma viruses, is a fusion of viral "gag" protein with the SH2 and SH3 domains of cellular Crk.[9] The name Crk is from "CT10 Regulator of Kinase" where CT10 is the avian virus from which was isolated a protein, lacking kinase domains, but capable of stimulating phosphorylation of tyrosines in cells.[10]
Crk should not be confused with Src, which also has cellular (c-Src) and viral (v-Src) forms and is involved in some of the same signaling pathways but is a protein tyrosine-kinase.
CRK (gene) has been shown to interact with:
PDB gallery
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1b07: CRK SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR
1cka: STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE-CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 DOMAIN OF C-CRK
1ckb: STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE-CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 DOMAIN OF C-CRK
1ju5: Ternary complex of an Crk SH2 domain, Crk-derived phophopeptide, and Abl SH3 domain by NMR spectroscopy
1m30: Solution structure of N-terminal SH3 domain from oncogene protein c-Crk
1m3a: Solution structure of a circular form of the truncated N-terminal SH3 domain from oncogene protein c-Crk.
1m3b: Solution structure of a circular form of the N-terminal SH3 domain (A134C, E135G, R191G mutant) from oncogene protein c-Crk.
1m3c: Solution structure of a circular form of the N-terminal SH3 domain (E132C, E133G, R191G mutant) from oncogene protein c-Crk
2dvj: phosphorylated Crk-II
2eyv: SH2 domain of CT10-Regulated Kinase
2eyw: N-terminal SH3 domain of CT10-Regulated Kinase
2eyx: C-Terminal SH3 domain of CT10-Regulated Kinase
2eyy: CT10-Regulated Kinase isoform I
2eyz: CT10-Regulated Kinase isoform II
2ggr: Solution structure of the C-terminal SH3 domain of c-CrkII
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