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F r o m W i k i p e d i a , t h e f r e e e n c y c l o p e d i a
Adecatumumab (MT201) is a recombinant human IgG1 monoclonal antibody which is used to target tumor cells. It binds to the epithelial cell adhesion molecule (EpCAM - CD326), with the intent to trigger antibody-dependent cellular cytotoxicity . It was developed by Micromet Inc, which was acquired by Amgen .[1]
Adecatumumab has been used in clinical studies of treatment in colorectal, prostate [2] and breast cancers .[3] Phase II results were published in 2010.[4]
References
[ edit ]
^ Oberneder R, Weckermann D, Ebner B, Quadt C, Kirchinger P, Raum T, et al. (October 2006). "A phase I study with adecatumumab, a human antibody directed against epithelial cell adhesion molecule, in hormone refractory prostate cancer patients". European Journal of Cancer . 42 (15 ): 2530–8. doi :10.1016/j.ejca.2006.05.029 . PMID 16930989 .
^ Prang N, Preithner S, Brischwein K, Göster P, Wöppel A, Müller J, et al. (January 2005). "Cellular and complement-dependent cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell lines" . British Journal of Cancer . 92 (2 ): 342–9. doi :10.1038/sj.bjc.6602310 . PMC 2361858 . PMID 15655555 .
^ Schmidt M, Scheulen ME, Dittrich C, Obrist P, Marschner N, Dirix L, et al. (February 2010). "An open-label, randomized phase II study of adecatumumab, a fully human anti-EpCAM antibody, as monotherapy in patients with metastatic breast cancer" . Annals of Oncology . 21 (2 ): 275–82. doi :10.1093/annonc/mdp314 . PMID 19633042 .
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R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Adecatumumab&oldid=1213907993 "
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