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F r o m W i k i p e d i a , t h e f r e e e n c y c l o p e d i a
Pritumumab (PTB ) is a human monoclonal antibody targeted against glioma .[1] It works by binding to the ecto-domain of vimentin on the surface of cancer cells.[1] [2] developed by Nascent Biotech .
It is in clinical trials for the treatment of glioma .[3] [4] The FDA granted orphan drug designation in 2015.
The target of Pritumumab , cell surface vimentin, has been implicated in the replication of coronavirus, specifically in Severe acute respiratory syndrome coronavirus (SARS-CoV).[5]
PTB has been proposed as a potential treatment for COVID-19 and related Viral Infections.[6]
References
[ edit ]
^ "Nascent Biologics Proven Cancer Cure Back in the Hands Of U.S. Inventor After 27 Years In Japan" . Nascent Biologics. 1 October 2009. Archived from the original on 2011-07-14.
^ Clinical trial number NCT04396717 for "Safety Study of Pritumumab in Brain Cancer" at ClinicalTrials.gov
^ Yu YT, Chien SC, Chen IY, Lai CT, Tsay YG, Chang SC, Chang MF (January 2016). "Surface vimentin is critical for the cell entry of SARS-CoV" . Journal of Biomedical Science . 23 : 14. doi :10.1186/s12929-016-0234-7 . PMC 4724099 . PMID 26801988 .
^ "Race For Vaccine Intensifies As COVID-19 Second Wave of Outbreaks Threatens" . Financialnewsmedia.com . 17 June 2020.
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