Nardulli joined the university's lab run by Benita Katzenellenbogen, and eventually became a professor of the Department of Molecular and Integrative Physiology with her own lab, teaching and studying the effects of estrogen in women.[1][3][5]
Nardulli's work concentrated on the specifics of estrogen activities, including the proteins it binds with, and the mechanisms that the hormone uses to manipulate chromatin and DNA. According to Katzenellenbogen,
“Dr. Nardulli did pioneering work that identified the protein complexes with which the estrogen receptor associated, many previously unknown, and she and her laboratory associates went on to elucidate how these proteins collaborated with and modulated the activities of the estrogen receptor in breast cancer cells and tumors."[3]
Among the research topics explored by her team were the plasma membrane proteins and their effect on breast cancer cells as well as the proteins that these cells secrete. Later research focused on the brain and estrogen action in it.[3]
At the university, Nardulli "was particularly fond of spending time with the Hormone Chixx, a group of women from across campus who studied the effects of hormones in the body. She discovered that introducing students to the wonders of human physiology and endocrinology was extremely rewarding and was recognized for her teaching excellence."[1][2][3]
As an active member of the Endocrine Society, she served as "chair of the Advocacy and Public Outreach Core Committee and visited Washington, D.C., numerous times to meet with legislators on Capitol Hill and lobby for increased scientific research funding." She was also a member of the society's Scientific Statements Task Force and a member of the editorial board for the academic journalEndocrine Reviews and Molecular Endocrinology.[2]
Nardulli died at her home of cancer in 2018, aged 69.[1][3]
Schultz-Norton, J. R.; Ziegler, Y. S.; Nardulli, A. M. (2011). "ERα-associated protein networks". Trends in Endocrinology and Metabolism. 22 (4): 124–9. doi:10.1016/j.tem.2010.11.005. PMID21371903. S2CID28219981.
