| Bacteriophage pRNA | |
|---|---|
Predicted secondary structure and sequence conservation of Phage_pRNA
| |
| Identifiers | |
| Symbol | Phage_pRNA |
| Rfam | RF00044 |
| Other data | |
| RNA type | Gene |
| Domain(s) | Viruses |
| SO | SO:0000655 |
| PDB structures | PDBe |
Bacteriophage pRNA is a ncRNA element. During replication of linear dsDNA viruses, the viral genome is packaged into the pre-formed viral procapsid. The packaging of DNA into the procapsid requires a molecular motor, which uses ATP as energy to accomplish the energetically unfavorable motion. In some bacteriophage, an RNA (pRNA) molecule is a vital component of this motor.[1] Structural analyses of the packaging motor have demonstrated that the pRNA molecule has fivefold symmetry when attached to the prohead.[2][3][4] The pRNA is thought to be bound by the capsid connector protein.[4] Only the first 120 bases of the pRNA are essential for packing the viral DNA.[5][6] The pRNA is proposed to be composed of two domains, one corresponding to the first 120 bases and the second to the remaining 50 bases.[6] Nuclear cleavage occurs in the single strand region linking these two domains.[6]
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