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1 References  













Buclizine






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From Wikipedia, the free encyclopedia
  

Buclizine
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
ATC code
Identifiers

  • (RS)-1-[(4-chlorophenyl)- phenyl-methyl]-4- [(4-tert-butylphenyl) methyl] piperazine

CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.001.317 Edit this at Wikidata
Chemical and physical data
FormulaC28H33ClN2
Molar mass433.04 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture

  • Clc1ccc(cc1)C(c2ccccc2)N3CCN(CC3)Cc4ccc(cc4)C(C)(C)C

  • InChI=1S/C28H33ClN2/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24/h4-16,27H,17-21H2,1-3H3 checkY

  • Key:MOYGZHXDRJNJEP-UHFFFAOYSA-N checkY

 ☒NcheckY (what is this?)  (verify)

Buclizine is an antihistamine and anticholinergic of the diphenylmethylpiperazine group. It is considered to be an antiemetic, similar to meclizine.[1]

In the United Kingdom, buclizine is one of three drugs contained in Migraleve tablets, marketed by McNeil Healthcare for migraines.[2]

References[edit]

  1. ^ Mostafa GA, Al-Badr AA (2011). "Buclizine". Profiles Drug Subst Excip Relat Methodol. Profiles of Drug Substances, Excipients and Related Methodology. 36: 1–33. doi:10.1016/B978-0-12-387667-6.00001-4. ISBN 9780123876676. PMID 22469258.
  • ^ Behrendt WA, Cserepes J (1985). "Acute toxicity and analgesic action of a combination of buclizine, codeine and paracetamol ('Migraleve') in tablet and suppository form in rats". Pharmatherapeutica. 4 (5): 322–31. PMID 4070325.
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    • Retrieved from "https://en.wikipedia.org/w/index.php?title=Buclizine&oldid=1171140057"
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