Contents

CCBP2

Protein-coding gene in the species Homo sapiens

ACKR2
Identifiers
Aliases	ACKR2, CCBP2, CCR10, CCR9, CMKBR9, D6, hD6, atypical chemokine receptor 2
External IDs	OMIM: 602648; MGI: 1891697; HomoloGene: 992; GeneCards: ACKR2; OMA:ACKR2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.1 Start 42,804,752 bp[1] End 42,887,974 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F4 Start 121,727,421 bp[2] End 121,740,140 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta right lobe of liver testicle gonad tibial nerve sural nerve subcutaneous adipose tissue tibialis anterior muscle mucosa of transverse colon left coronary artery Top expressed in right lung lobe ankle left lung lobe embryo skin of external ear carotid body decidua gastrula submandibular gland mesenteric lymph nodes More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity chemokine receptor activity C-C chemokine binding G protein-coupled receptor activity scavenger receptor activity C-C chemokine receptor activity chemokine binding Cellular component integral component of membrane early endosome recycling endosome membrane actin filament endosome plasma membrane integral component of plasma membrane nucleoplasm cytosol nuclear membrane intracellular membrane-bounded organelle external side of plasma membrane Biological process signal transduction multicellular organism development inflammatory response immune response chemokine-mediated signaling pathway G protein-coupled receptor signaling pathway chemotaxis receptor-mediated endocytosis positive regulation of cytosolic calcium ion concentration calcium-mediated signaling cell chemotaxis vesicle-mediated transport endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1238 59289 Ensembl ENSG00000144648 ENSMUSG00000044534 UniProt O00590 O08707 RefSeq (mRNA) NM_001296 NM_001276719 NM_021609 RefSeq (protein) NP_001287 NP_001263648 NP_067622 Location (UCSC) Chr 3: 42.8 – 42.89 Mb Chr 9: 121.73 – 121.74 Mb PubMed search [3] [4]
Wikidata
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Chemokine-binding protein 2 is a protein that in humans is encoded by the CCBP2 gene.^[5][6][7]

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.^[7]

References[edit]

Further reading[edit]

External links[edit]

• Human ACKR2 genome location and ACKR2 gene details page in the UCSC Genome Browser.
• Human CCR10 genome location and CCR10 gene details page in the UCSC Genome Browser.
• Human CCR9 genome location and CCR9 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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