Contents

IL18R1

Protein-coding gene in the species Homo sapiens

IL18R1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WO3, 3WO4, 4R6U
Identifiers
Aliases	IL18R1, CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP, interleukin 18 receptor 1, IL-18R-alpha, IL18Ralpha2, IL-18Ralpha
External IDs	OMIM: 604494; MGI: 105383; HomoloGene: 2861; GeneCards: IL18R1; OMA:IL18R1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q12.1 Start 102,311,529 bp[1] End 102,398,777 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 B Start 40,504,712 bp[2] End 40,540,014 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung upper lobe of left lung testicle blood granulocyte spleen appendix gallbladder right lobe of liver left uterine tube Top expressed in right lung lobe left lung conjunctival fornix granulocyte left lung lobe blood transitional epithelium of urinary bladder mesenteric lymph nodes spleen pharynx More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interleukin-18 receptor activity protein binding interleukin-1 receptor activity signaling receptor activity interleukin-18 binding Cellular component integral component of membrane plasma membrane membrane interleukin-18 receptor complex Biological process natural killer cell activation positive regulation of interferon-gamma production T-helper 1 cell differentiation immune response signal transduction interleukin-18-mediated signaling pathway cellular response to cytokine stimulus positive regulation of NIK/NF-kappaB signaling positive regulation of NF-kappaB transcription factor activity positive regulation of T-helper 1 cell cytokine production inflammatory response negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8809 16182 Ensembl ENSG00000115604 ENSMUSG00000026070 UniProt Q13478 Q61098 RefSeq (mRNA) NM_001282399 NM_003855 NM_001371418 NM_001371419 NM_001371420 NM_001371421 NM_001371422 NM_001371423 NM_001371424 NM_001161842 NM_001161843 NM_008365 RefSeq (protein) NP_001269328 NP_003846 NP_001358347 NP_001358348 NP_001358349 NP_001358350 NP_001358351 NP_001358352 NP_001358353 NP_001155314 NP_001155315 NP_032391 Location (UCSC) Chr 2: 102.31 – 102.4 Mb Chr 1: 40.5 – 40.54 Mb PubMed search [3] [4]
Wikidata
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The interleukin-18 receptor 1 (IL-18R1) is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is its human gene.^[5] IL18R1 is also known as CDw218a (cluster of differentiation w218a).

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.^[5]

See also[edit]

• Interleukin-18 receptor

References[edit]

Further reading[edit]

External links[edit]

• IL18R1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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