Contents

CCL28

CCL28
Identifiers
Aliases	CCL28, CCK1, MEC, SCYA28, C-C motif chemokine ligand 28
External IDs	OMIM: 605240; MGI: 1861731; HomoloGene: 10649; GeneCards: CCL28; OMA:CCL28 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p12 Start 43,376,645 bp[1] End 43,412,391 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 D2.3 Start 120,085,355 bp[2] End 120,115,895 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland pancreatic ductal cell minor salivary glands rectum olfactory zone of nasal mucosa mucosa of colon epithelium of lactiferous gland mucosa of sigmoid colon lactiferous duct mucosa of transverse colon Top expressed in lacrimal gland salivary gland Paneth cell submandibular gland parotid gland left colon duodenum proximal tubule right kidney ileum More reference expression data BioGPS n/a
Gene ontology Molecular function chemokine activity cytokine activity protein binding Cellular component extracellular region extracellular exosome extracellular space secretory granule Biological process cell chemotaxis chemotaxis positive regulation of cytosolic calcium ion concentration negative regulation of leukocyte tethering or rolling immune response positive regulation of cell-matrix adhesion response to nutrient antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56477 56838 Ensembl ENSG00000151882 ENSMUSG00000074715 UniProt Q9NRJ3 Q9JIL2 RefSeq (mRNA) NM_001301873 NM_001301874 NM_001301875 NM_019846 NM_148672 NM_020279 RefSeq (protein) NP_001288802 NP_001288803 NP_001288804 NP_683513 NP_064675 Location (UCSC) Chr 5: 43.38 – 43.41 Mb Chr 13: 120.09 – 120.12 Mb PubMed search [3] [4]
Wikidata
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Chemokine (C-C motif) ligand 28 (CCL28), also known as mucosae-associated epithelial chemokine (MEC), CCK1 and SCYA28, is a chemokine. CCL28 regulates the chemotaxis of cells that express the chemokine receptors CCR3 and CCR10. CCL28 is expressed by columnar epithelial cells in the gut, lung, breast and the salivary glands and drives the mucosal homing of T and B lymphocytes that express CCR10, and the migration of eosinophils expressing CCR3.^[5][6][7] This chemokine is constitutively expressed in the colon, but its levels can be increased by pro-inflammatory cytokines and certain bacterial products implying a role in effector cell recruitment to sites of epithelial injury.^[8] CCL28 has also been implicated in the migration of IgA-expressing cells to the mammary gland,^[9] salivary gland, intestine^[10] and other mucosal tissues.^[11] It has also been shown as a potential antimicrobial agent effective against certain pathogens, such as Gram negative and Gram positive bacteria and the fungus Candida albicans.^[8]

Human CCL28 is encoded by an RNA transcript of 373 nucleotides and a gene with four exons. The gene codes for a 127-amino acid CCL28 protein with a 22-amino acid N-terminal signal peptide. It shares 76% nucleic acid identity and 83% amino acid similarity to the equivalent molecule in mouse.^[12][13] Sequence analysis has revealed CCL28 to be most similar to another CC chemokine called CCL27.

Gene neighbourhood[edit]

The gene C5orf34 is found downstream of CCL28 and is a predicted to be in the Polo-like Kinase family. C5orf34 extends from base pair 43,486,701 to base pair 43,515,445.^[14]

References[edit]