C-X-C chemokine receptor type 6 is a protein that in humans is encoded by the CXCR6 gene.[5][6][7] CXCR6 has also recently been designated CD186 (cluster of differentiation 186).
CXCR6 has been identified as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4.[5][6][7][8] It is a minor coreceptor for HIV-1, nearly all strains of which use CCR5 and/or CXCR4. Most SIV strains can use CXCR6 and recent evidence suggests that in monkeys that serve as the natural hosts of SIV, CXCR6 may be a major coreceptor.[8] CXCR6 was previously known as "Bonzo" and "STRL33" in the HIV/SIV field.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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Chemokine receptor (GPCRs) |
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TNF receptor |
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JAK-STAT |
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Ig superfamily |
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IL 17 family |
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Enzyme-linked receptor |
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CC |
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CXC |
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C (XC) |
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CX3C |
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Others |
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