Cadherin-11 is a protein that in humans is encoded by the CDH11 gene.[5][6]
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.[6] The mammalian CDH-11 homologues are termed calsyntenin.[7]
CDH11 is overexpressed in 15% of breast cancers and seems essential to tumour progression in some other cancer types.[8][9]
Arthritis drug celecoxib binds to CDH11.[8][9]
CDH11 has been shown to interact with CDH2.[10]
PDB gallery
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2a4c: Crystal structure of mouse cadherin-11 EC1
2a4e: Crystal structure of mouse cadherin-11 EC1-2
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Calcium-independent |
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Calcium-dependent |
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