CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene.[5][6]
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.[7]
CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor.[8]
One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy.[9]
Function of CEBPD gene can be effectively examined by siRNA knockdown based on an independent validation.[10]
CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.[11]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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