Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene.[5][6]
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.[7]
CLTC has been shown to interact with PICALM[8] and HGS.[9]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
PDB gallery
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1b89: CLATHRIN HEAVY CHAIN PROXIMAL LEG SEGMENT (BOVINE)
1bpo: CLATHRIN HEAVY-CHAIN TERMINAL DOMAIN AND LINKER
1c9i: PEPTIDE-IN-GROOVE INTERACTIONS LINK TARGET PROTEINS TO THE B-PROPELLER OF CLATHRIN
1c9l: PEPTIDE-IN-GROOVE INTERACTIONS LINK TARGET PROTEINS TO THE B-PROPELLER OF CLATHRIN
1utc: CLATHRIN TERMINAL DOMAIN COMPLEXED WITH TLPWDLWTT
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Synaptic vesicle |
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COPI |
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COPII |
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RME/Clathrin |
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Caveolae |
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Other/ungrouped |
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