PLIN3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | PLIN3, M6PRBP1, PP17, TIP47, perilipin 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 602702; MGI: 1914155; HomoloGene: 4247; GeneCards: PLIN3; OMA:PLIN3 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Mannose-6-phosphate receptor binding protein 1 (M6PRBP1) is a protein which in humans is encoded by the M6PRBP1 gene.[5] Its gene product, as well as the gene itself, is commonly known as TIP47.
Mannose 6-phosphate receptors (MPRs) deliver lysosomal hydrolase from the Golgitoendosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo.[6]
The mannose-6-phosphate receptor-binding properties of TIP47 are disputed,[7] despite the designation of M6PRBP1 as TIP47's gene symbol. TIP47 protein is most commonly described in the scientific literature as a coat protein for lipid droplets.[8]
TIP47 belongs to the peripilin protein family and shares significant homology with the other genes of this family, including perilipin and adipophilin.[9]
M6PRBP1 has been shown to interact with both Mannose 6-phosphate receptors.[10][11]
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Synaptic vesicle |
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COPI |
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COPII |
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RME/Clathrin |
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Caveolae |
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Other/ungrouped |
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