Collagen alpha-2(IV) chain is a protein that in humans is encoded by the COL4A2 gene.[5][6][7]
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.[7]
PDB gallery
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1li1: The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link
1m3d: Structure of Type IV Collagen NC1 Domains
1t60: Crystal structure of Type IV collagen NC1 domain from bovine lens capsule
1t61: crystal structure of collagen IV NC1 domain from placenta basement membrane
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Extracellular matrix |
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