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Collagen, type V, alpha 3

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COL5A3

Identifiers

Aliases

COL5A3, collagen type V alpha 3 chain

External IDs

OMIM: 120216; MGI: 1858212; HomoloGene: 9253; GeneCards: COL5A3; OMA:COL5A3 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.2	Start	9,959,561 bp^[1]
Band	19p13.2	End	10,010,504 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 A3	Start	20,681,346 bp^[2]
Band	9\|9 A3	End	20,726,363 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sural nerve

apex of heart

canal of the cervix

subcutaneous adipose tissue

left uterine tube

putamen

ectocervix

amygdala

right frontal lobe

dorsal motor nucleus of vagus nerve

Top expressed in

sciatic nerve

white adipose tissue

ankle

subcutaneous adipose tissue

belly cord

lumbar spinal ganglion

trachea

soleus muscle

vastus lateralis muscle

brown adipose tissue

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	heparin binding extracellular matrix structural constituent collagen binding extracellular matrix structural constituent conferring tensile strength proteoglycan binding
Cellular component	collagen type V trimer extracellular region collagen endoplasmic reticulum lumen extracellular matrix extracellular space collagen-containing extracellular matrix
Biological process	collagen catabolic process cell-matrix adhesion extracellular matrix organization skin development collagen fibril organization cell adhesion
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


50509


53867

Ensembl


ENSG00000080573


ENSMUSG00000004098

UniProt


P25940


Q9JLI2

RefSeq (mRNA)


NM_015719


NM_016919 NM_001317388

RefSeq (protein)


NP_056534


NP_001304317 NP_058615

Location (UCSC)

Chr 19: 9.96 – 10.01 Mb

Chr 9: 20.68 – 20.73 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Collagen alpha-3(V) chain is a protein that in humans is encoded by the COL5A3 gene.^[5]^[6]

This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are thought to be responsible for the symptoms of a subset of patients with Ehlers-Danlos syndrome type III. Messages of several sizes can be detected in northern blots but sequence information cannot confirm the identity of the shorter messages.^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000080573 – Ensembl, May 2017

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004098 – Ensembl, May 2017

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

^ Imamura Y, Scott IC, Greenspan DS (Apr 2000). "The pro-alpha3(V) collagen chain. Complete primary structure, expression domains in adult and developing tissues, and comparison to the structures and expression domains of the other types V and XI procollagen chains". J Biol Chem. 275 (12): 8749–59. doi:10.1074/jbc.275.12.8749. PMID 10722718.

^ ^a ^b "Entrez Gene: COL5A3 collagen, type V, alpha 3".

Further reading[edit]

van der Rest M, Garrone R (1991). "Collagen family of proteins". FASEB J. 5 (13): 2814–23. doi:10.1096/fasebj.5.13.1916105. PMID 1916105. S2CID 11261357.

Fichard A, Kleman JP, Ruggiero F (1996). "Another look at collagen V and XI molecules". Matrix Biol. 14 (7): 515–31. doi:10.1016/S0945-053X(05)80001-0. PMID 8535602.

Mann K (1992). "Isolation of the alpha 3-chain of human type V collagen and characterization by partial sequencing". Biol. Chem. Hoppe-Seyler. 373 (2): 69–75. doi:10.1515/bchm3.1992.373.1.69. PMID 1571108.

Niyibizi C, Fietzek PP, van der Rest M (1984). "Human placenta type V collagens. Evidence for the existence of an alpha 1(V) alpha 2(V) alpha 3(V) collagen molecule". J. Biol. Chem. 259 (22): 14170–4. doi:10.1016/S0021-9258(18)89872-6. PMID 6501291.

Abedin MZ, Ayad S, Weiss JB (1982). "Isolation and native characterization of cysteine-rich collagens from bovine placental tissues and uterus and their relationship to types IV and V collagens". Biosci. Rep. 2 (7): 493–502. doi:10.1007/BF01115247. PMID 7115902. S2CID 22620593.

Rhodes RK, Miller EJ (1982). "Evidence for the existence of an alpha 1(V) alpha 2(V) alpha 3(V) collagen molecule in human placental tissue". Coll. Relat. Res. 1 (4): 337–43. doi:10.1016/S0174-173X(81)80010-6. PMID 7346227.