Contents

CXCL3

Mammalian protein found in Homo sapiens

CXCL3
Identifiers
Aliases	CXCL3, CINC-2b, GRO3, GROg, MIP-2b, MIP2B, SCYB3, C-X-C motif chemokine ligand 3
External IDs	OMIM: 139111; MGI: 1340094; HomoloGene: 117695; GeneCards: CXCL3; OMA:CXCL3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.3 Start 74,036,589 bp[1] End 74,038,807 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 E1|5 44.78 cM Start 91,051,730 bp[2] End 91,053,797 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue testicle mucosa of paranasal sinus pylorus pancreatic epithelial cell appendix upper lobe of left lung rectum olfactory zone of nasal mucosa islet of Langerhans Top expressed in granulocyte stroma of bone marrow embryo endothelial cell of lymphatic vessel embryo islet of Langerhans spermatid lumbar subsegment of spinal cord lumbar spinal ganglion thymus More reference expression data BioGPS n/a
Gene ontology Molecular function chemokine activity cytokine activity CXCR chemokine receptor binding Cellular component extracellular region extracellular space Biological process chemokine-mediated signaling pathway chemotaxis response to lipopolysaccharide inflammatory response regulation of cell population proliferation immune response neutrophil chemotaxis positive regulation of neutrophil chemotaxis defense response antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity G protein-coupled receptor signaling pathway leukocyte chemotaxis cellular response to lipopolysaccharide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2921 20310 Ensembl ENSG00000163734 ENSMUSG00000058427 UniProt P19876 P10889 RefSeq (mRNA) NM_002090 NM_009140 RefSeq (protein) NP_002081 NP_033166 Location (UCSC) Chr 4: 74.04 – 74.04 Mb Chr 5: 91.05 – 91.05 Mb PubMed search [3] [4]
Wikidata
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Chemokine (C-X-C motif) ligand 3 (CXCL3) is a small cytokine belonging to the CXC chemokine family that is also known as GRO3 oncogene (GRO3), GRO protein gamma (GROg) and macrophage inflammatory protein-2-beta (MIP2b). CXCL3 controls migration and adhesionofmonocytes and mediates its effects on its target cell by interacting with a cell surface chemokine receptor called CXCR2.^[5][6] More recently, it has been shown that Cxcl3 regulates cell autonomously the migration of the precursors of cerebellar granule neurons toward the internal layers of cerebellum, during the morphogenesis of cerebellum.^[7] Moreover, if the expression of Cxcl3 is reduced in cerebellar granule neuron precursors, this highly enhances the frequency of the medulloblastoma, the tumor of cerebellum. In fact, the reduced expression of Cxcl3 forces the cerebellar granule neuron precursors to remain at the surface of the cerebellum, where they highly proliferate under the stimulus of Sonic hedgehog, becoming target of transforming insults. Remarkably, the treatment with CXCL3 completely prevents the growth of medulloblastoma lesions in a Shh-type mouse model of medulloblastoma.^[8] Thus, CXCL3 is a target for medulloblastoma therapy. Cxcl3 is directly regulated transcriptionally by BTG2^[7]

The gene for CXCL3 is located on chromosome 4 in a cluster of other CXC chemokines.^[9]

References[edit]

External links[edit]

• Human CXCL3 genome location and CXCL3 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.