Contents

DDX19B

Protein-coding gene in the species Homo sapiens

DDX19B
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3EWS, 3FHC, 3FHT, 3FMO, 3FMP, 3G0H
Identifiers
Aliases	DDX19B, DBP5, DDX19, RNAh, DEAD-box helicase 19B
External IDs	OMIM: 605812; MGI: 2148251; HomoloGene: 56032; GeneCards: DDX19B; OMA:DDX19B - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 70,289,663 bp[1] End 70,335,305 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 111,729,820 bp[2] End 111,758,383 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis Achilles tendon skin of leg ganglionic eminence gastric mucosa granulocyte bone marrow cells ventricular zone gastrocnemius muscle Top expressed in spermatocyte Ileal epithelium spermatid secondary oocyte lesser wing of sphenoid bone lumbar spinal ganglion seminiferous tubule zygote neural layer of retina epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding hydrolase activity ATP binding helicase activity RNA binding nucleic acid binding Cellular component nuclear envelope nuclear pore nuclear membrane extracellular exosome membrane nucleus catalytic step 2 spliceosome nucleolus cytoplasm Biological process protein transport mRNA transport RNA secondary structure unwinding mRNA export from nucleus RNA splicing regulation of gene expression transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11269 234733 Ensembl ENSG00000157349 ENSMUSG00000033658 UniProt Q9UMR2 n/a RefSeq (mRNA) NM_001014449 NM_001014451 NM_001257172 NM_001257173 NM_001257174 NM_001257175 NM_007242 NM_001363938 NM_001190786 NM_001190800 NM_172284 RefSeq (protein) NP_001014449 NP_001014451 NP_001244101 NP_001244102 NP_001244103 NP_001244104 NP_009173 NP_001350867 n/a Location (UCSC) Chr 16: 70.29 – 70.34 Mb Chr 8: 111.73 – 111.76 Mb PubMed search [3] [4]
Wikidata
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ATP-dependent RNA helicase DDX19B is an enzyme that in humans is encoded by the DDX19B gene.^[5][6]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[6]

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Further reading[edit]

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