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Denopamine

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Denopamine
Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	Oral (tablets)
ATC code	none
Legal status
Legal status	Rx-only (JP)
Identifiers
IUPAC name 4-[(1S)-2-[2-(3,4-dimethoxyphenyl)ethylamino]-1-hydroxyethyl]phenol
CAS Number	71771-90-9
PubChem CID	71754
IUPHAR/BPS	534
ChemSpider	64795
UNII	V5F60UPD8P
KEGG	D02614
ChEMBL	ChEMBL493682
CompTox Dashboard (EPA)	DTXSID8045800
ECHA InfoCard	100.163.233
Chemical and physical data
Formula	C₁₈H₂₃NO₄
Molar mass	317.385 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O(c1ccc(cc1OC)CCNC[C@@H](O)c2ccc(O)cc2)C

Denopamine (INN) is a cardiotonic drug which acts as a β₁ adrenergic receptor agonist.^[1] It is used in the treatment of angina^[2] and may also have potential uses in the treatment of congestive heart failure^[3] and for clearing pulmonary oedema.^[4] It is marketed in Japan under the brand name Kalgut (カルグート) and available as tablets of 5 and 10 mg, and 5% fine granules.^[5]

References[edit]

^ Ishide T (2002). "Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator". Current Medical Research and Opinion. 18 (7): 407–13. doi:10.1185/030079902125001119. PMID 12487507. S2CID 25048757.

^ Nakajima D, Negoro N, Nakaboh A, Nakakoji T, Hoshiga M, Nariyama J, et al. (April 2006). "Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment". International Journal of Cardiology. 108 (2): 281–3. doi:10.1016/j.ijcard.2005.03.012. PMID 15913812.

^ Nishio R, Matsumori A, Shioi T, Wang W, Yamada T, Ono K, Sasayama S (September 1998). "Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart". Journal of the American College of Cardiology. 32 (3): 808–15. doi:10.1016/S0735-1097(98)00314-3. hdl:2433/181223. PMID 9741531.