Desmoplastic trichoepithelioma is a cutaneous condition characterized by a solitary, firm skin lesion on the face.[1]: 672 Familial cases have been reported suggesting a possible genetic link.
The diagnosis is made based on clinical and morphological features. Differential diagnosis includes trichoepithelioma, microcystic adnexal carcinoma, morpheaform basal cell carcinoma, and syringoma.
Surgical excision is the treatment of choice.
Desmoplastic trichoepithelioma is more common in females and usually affects children or adults.
Desmoplastic trichoepithelioma manifests as a firm, soft, or white to yellowish annular noduleorpapule on the cheeks or face with a central indentation.[2]
Desmoplastic trichoepithelioma can be diagnosed based on clinical and morphological features. Desmoplastic trichoepithelioma may resemble other tumors such as conventional trichoepithelioma, microcystic adnexal carcinoma, morpheaform basal cell carcinoma, and syringoma both clinically and histopathologically.[4]
The preferred course of treatment is surgical excision.[2] Nonetheless, Mohs microscopic surgery is the method of choice for lesions, particularly those on the face.[5]
Desmoplastic trichoepithelioma is more common in females. It has a bimodal age distribution and usually affects adults or small children. Desmoplastic trichoepithelioma accounts for less than 1% of all cutaneous tumors.[2]
Mamelak, Adam J.; Goldberg, Leonard H.; Katz, Tracy M.; Graves, Jeffery J.; Arnon, Ofer; Kimyai-Asadi, Arash (2010). "Desmoplastic trichoepithelioma". Journal of the American Academy of Dermatology. 62 (1). Elsevier BV: 102–106. doi:10.1016/j.jaad.2009.06.066. ISSN0190-9622. PMID20082889.
Moynihan, Gavan D.; Skrokov, Robert A.; Huh, Julie; Pardes, Jeffrey B.; Septon, Robin (2011). "Desmoplastic trichoepithelioma". Journal of the American Academy of Dermatology. 64 (2). Elsevier BV: 438–439. doi:10.1016/j.jaad.2010.04.053. ISSN0190-9622.
