Diencephalic syndrome, or Russell's syndrome, is a rare neurological disorder seen in infants and children and characterised by failure to thrive and severe emaciation despite normal or slightly decreased caloric intake. Classically there is also locomotor hyperactivity and euphoria. Less commonly diencephalic syndrome may involve skin pallor without anaemia, hypoglycaemia, and hypotension.[1] The syndrome is a rare but potentially fatal cause of failure to thrive in children. Failure to thrive presents on average at seven months of age.[1] Of note the syndrome is not associated with developmental delay.[2] There may be associated hydrocephalus.[citation needed]
Diencephalic syndrome was first described by Dr. A. Russell in 1951.[3] It is usually caused by a brain tumor such as a low-grade gliomaorastrocytoma located in the hypothalamic-optic chiasmatic region.[1] It is not yet understood how diencephalic syndrome causes the effects on appetite and metabolism which are seen, though inappropriately high growth hormone release has been proposed,[4] as has excessive β-lipotropin secretion[1] and overall increased metabolic demand.[5] It is treated with nutritional optimisation while the underlying lesion is treated with chemotherapy, surgeryorradiotherapy.[citation needed]
^Fleischman A, Brue C, Poussaint TY, Kieran M, Pomeroy SL, Goumnerova L, Scott RM, Cohen LE (June 2005). "Diencephalic syndrome: a cause of failure to thrive and a model of partial growth hormone resistance". Pediatrics. 115 (6): 724–6. doi:10.1542/peds.2004-2237. PMID15930202. S2CID11980144.
^Drop SL, Guyda HJ, Colle E (August 1980). "Inappropriate growth hormone release in the diencephalic syndrome of childhood: case report and 4 year endocrinological follow-up". Clin Endocrinol. 13 (2): 181–7. doi:10.1111/j.1365-2265.1980.tb01040.x. PMID7438472. S2CID41448424.
^Vlachopapadopoulou E, Tracey KJ, Capella M, Gilker C, Matthews DE (June 1993). "Increased energy expenditure in a patient with diencephalic syndrome". J Pediatr. 122 (6): 922–4. doi:10.1016/s0022-3476(09)90021-x. PMID8501572.