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1 See also  





2 References  














Diflucortolone valerate






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From Wikipedia, the free encyclopedia
 


Diflucortolone valerate
Names
IUPAC name

6α,9-Difluoro-11β-hydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl pentanoate

Systematic IUPAC name

2-[(1S,2R,3aS,3bS,5S,9aS,9bR,10S,11aS)-5,9b-Difluoro-10-hydroxy-2,9a,11a-trimethyl-7-oxo-2,3,3a,3b,4,5,7,9a,9b,10,11,11a-dodecahydro-1H-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl pentanoate

Other names

Afusona; Diflucortolone 21-valerate

Identifiers

CAS Number

3D model (JSmol)

ChEMBL
ChemSpider
ECHA InfoCard 100.056.032 Edit this at Wikidata

PubChem CID

UNII

CompTox Dashboard (EPA)

  • InChI=1S/C27H36F2O5/c1-5-6-7-23(33)34-14-21(31)24-15(2)10-17-18-12-20(28)19-11-16(30)8-9-26(19,4)27(18,29)22(32)13-25(17,24)3/h8-9,11,15,17-18,20,22,24,32H,5-7,10,12-14H2,1-4H3/t15-,17+,18+,20+,22+,24-,25+,26+,27+/m1/s1 checkY

    Key: HHJIUUAMYGBVSD-YTFFSALGSA-N checkY

  • InChI=1/C27H36F2O5/c1-5-6-7-23(33)34-14-21(31)24-15(2)10-17-18-12-20(28)19-11-16(30)8-9-26(19,4)27(18,29)22(32)13-25(17,24)3/h8-9,11,15,17-18,20,22,24,32H,5-7,10,12-14H2,1-4H3/t15-,17+,18+,20+,22+,24-,25+,26+,27+/m1/s1

    Key: HHJIUUAMYGBVSD-YTFFSALGBY

  • O=C(OCC(=O)[C@@H]3[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C)CCCC

Properties

Chemical formula

C27H36F2O5
Molar mass 478.577 g·mol−1
Melting point 220 °C (428 °F; 493 K)[1]

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

checkY verify (what is checkY☒N ?)

Infobox references

Diflucortolone valerate (also Nerisone cream/ointment/fatty ointment, Neriderm ointment, Japanese ジフルコルトロン (Jifurucorutoron)) is a corticosteroid rated Class 3 "potent" (100–150 times) in the New Zealand topical steroid system. It is a white to creamy white crystalline powder. It is practically insoluble in water, freely soluble in dichloromethane and in dioxan, sparingly soluble in ether and slightly soluble in methyl alcohol. Chemically, it is a corticosteroid esterified with valeric acid. It is commonly used topicallyindermatology. The brand name is Nerisone; its creams come in potencies of 0.1% and 0.3%.

See also[edit]

References[edit]



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