Contents

EPH receptor B4

Protein-coding gene in the species Homo sapiens

EPHB4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BBA, 2E7H, 2QKQ, 2VWU, 2VWV, 2VWW, 2VWX, 2VWY, 2VWZ, 2VX0, 2VX1, 2X9F, 2XVD, 2YN8, 3ZEW, 4AW5, 4BB4, 2HLE
Identifiers
Aliases	EPHB4, Ephb4, AI042935, Htk, MDK2, Myk1, Tyro11, EPH receptor B4, HTK, MYK1, TYRO11, HFASD, CMAVM2, LMPHM7
External IDs	OMIM: 600011; MGI: 104757; HomoloGene: 20939; GeneCards: EPHB4; OMA:EPHB4 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 100,802,565 bp[1] End 100,827,523 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 137,348,371 bp[2] End 137,376,931 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory bulb beta cell body of uterus right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex right lung ectocervix canal of the cervix Top expressed in tail of embryo genital tubercle otic vesicle saccule atrium yolk sac left ventricle aortic valve lip maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein binding transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding ephrin receptor activity transmembrane-ephrin receptor activity Cellular component integral component of membrane cytosol membrane plasma membrane integral component of plasma membrane extracellular region extracellular exosome neuron projection receptor complex Biological process phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway heart morphogenesis cell migration involved in sprouting angiogenesis multicellular organism development protein phosphorylation cell adhesion angiogenesis protein autophosphorylation peptidyl-tyrosine phosphorylation ephrin receptor signaling pathway axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2050 13846 Ensembl ENSG00000196411 ENSMUSG00000029710 UniProt P54760 P54761 RefSeq (mRNA) NM_004444 NM_001159571 NM_010144 RefSeq (protein) NP_004435 NP_001153043 NP_034274 Location (UCSC) Chr 7: 100.8 – 100.83 Mb Chr 5: 137.35 – 137.38 Mb PubMed search [3] [4]
Wikidata
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Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene.^[5][6]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.^[6][7]

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