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Erythema multiforme major

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Erythema multiforme major
Other names	Erythema multiforme majus^[1]

Micrograph of confluent epidermal necrosis. H&E stain.
Specialty	Dermatology

Indermatology, erythema multiforme major is a form of rash with skin loss or epidermal detachment.

The term "erythema multiforme majus" is sometimes used to imply a bullous (blistering) presentation.^[2]

According to some sources, there are two conditions included on a spectrum of this same disease process:

Stevens–Johnson syndrome (SJS)
Toxic epidermal necrolysis (TEN) which described by Alan Lyell and previously called Lyell syndrome[5].

In this view, EM major, SJS and TEN are considered a single condition, distinguished by degree of epidermal detachment.^[3]^[4]

However, a consensus classification separates erythema multiforme minor, erythema multiforme major, and SJS/TEN as three separate entities.^[3]

References

[edit]

^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.

^ Daniel J. Trozak; Dan J. Tennenhouse (1 October 2005). Dermatology skills for primary care: an illustrated guide. Humana Press. pp. 161–. ISBN 978-1-58829-489-0. Archived from the original on 21 June 2013. Retrieved 5 June 2010.

^ ^a ^b "Erythema Multiforme: eMedicine Emergency Medicine". 2019-02-02. Archived from the original on 2010-08-06. {{cite journal}}: Cite journal requires |journal= (help)