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| FENDRR | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | FENDRR, FOXF1-AS1, TCONS_00024240, lincFOXF1, onco-lncRNA-21, FOXF1 adjacent non-coding developmental regulatory RNA, FOXF1AS1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 614975; GeneCards: FENDRR; OMA:FENDRR - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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FOXF1 adjacent non-coding developmental regulatory RNA is a long non-coding RNA that in humans is encoded by the FENDRR gene. [3]
This gene produces a spliced long non-coding RNA transcribed bidirectionally with FOXF1 on the opposite strand. A similar gene in mouse is essential for normal development of the heart and body wall. The encoded transcript is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It has been suggested that this transcript may play a role in the progression of gastric cancer. Alternatively spliced transcript variants have been identified.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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