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M a i n m e n u
M a i n m e n u
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● M a i n p a g e ● C o n t e n t s ● C u r r e n t e v e n t s ● R a n d o m a r t i c l e ● A b o u t W i k i p e d i a ● C o n t a c t u s ● D o n a t e
C o n t r i b u t e
● H e l p ● L e a r n t o e d i t ● C o m m u n i t y p o r t a l ● R e c e n t c h a n g e s ● U p l o a d f i l e
S e a r c h
Search
A p p e a r a n c e
● C r e a t e a c c o u n t ● L o g i n
P e r s o n a l t o o l s
● C r e a t e a c c o u n t ● L o g i n
P a g e s f o r l o g g e d o u t e d i t o r s l e a r n m o r e ● C o n t r i b u t i o n s ● T a l k
( T o p )
1 A v a i l a b l e f o r m s
2 H i s t o r y
3 S o c i e t y a n d c u l t u r e
T o g g l e S o c i e t y a n d c u l t u r e s u b s e c t i o n
3 . 1 E c o n o m i c s
4 S e e a l s o
5 R e f e r e n c e s
6 E x t e r n a l l i n k s
T o g g l e t h e t a b l e o f c o n t e n t s
F a c t o r V I I I ( m e d i c a t i o n )
9 l a n g u a g e s
● ا ل ع ر ب ي ة ● E s p a ñ o l ● ف ا ر س ی ● F r a n ç a i s ● Հ ա յ ե ր ե ն ● B a h a s a M e l a y u ● 日 本 語 ● ଓ ଡ ଼ ି ଆ ● T i ế n g V i ệ t
E d i t l i n k s
● A r t i c l e ● T a l k
E n g l i s h
● R e a d ● E d i t ● V i e w h i s t o r y
T o o l s
T o o l s
A c t i o n s
● R e a d ● E d i t ● V i e w h i s t o r y
G e n e r a l
● W h a t l i n k s h e r e ● R e l a t e d c h a n g e s ● U p l o a d f i l e ● S p e c i a l p a g e s ● P e r m a n e n t l i n k ● P a g e i n f o r m a t i o n ● C i t e t h i s p a g e ● G e t s h o r t e n e d U R L ● D o w n l o a d Q R c o d e ● W i k i d a t a i t e m
P r i n t / e x p o r t
● D o w n l o a d a s P D F ● P r i n t a b l e v e r s i o n
A p p e a r a n c e
F r o m W i k i p e d i a , t h e f r e e e n c y c l o p e d i a
Factor VIII is a medication used to treat and prevent bleeding in people with hemophilia A and other causes of low factor VIII .[10] [11] von Willebrand's disease .[11] slow injection into a vein .[10]
Side effects include skin flushing, shortness of breath, fever , and red blood cell breakdown .[10] [11] Allergic reactions including anaphylaxis may occur.[11] pregnancy is safe for the fetus.[12] blood plasma .[11] A recombinant version is also available.[10] antibodies to factor VIII such that this medication becomes less effective.[12]
Factor VIII was first identified in the 1940s and became available as a medication in the 1960s.[13] [14] [15] [16] World Health Organization's List of Essential Medicines .[17]
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Factor VIII is delivered by intravenous infusion .[18]
History
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This transfer of a plasma byproduct into the blood stream of a hemophiliac often led to the transmission of diseases such as HIV and hepatitis before purification methods were improved. In the early 1990s, pharmaceutical companies began to produce recombinant synthesized factor products, which now prevent nearly all forms of disease transmission during replacement therapy.[citation needed
Society and culture
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Economics
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The cost of Factor VIII and similar clotting factors has been described as "highly expensive".[18] [19] gene therapy for haemophilia might be less expensive, especially for people with severe hemophilia.[19]
See also
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References
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^ "Prescription medicines: registration of new chemical entities in Australia, 2016" . Therapeutic Goods Administration (TGA) . 21 June 2022. Retrieved 10 April 2023 .
^ "Prescription medicines: registration of new chemical entities in Australia, 2014" . Therapeutic Goods Administration (TGA) . 21 June 2022. Retrieved 10 April 2023 .
^ "Prescription medicines and biologicals: TGA annual summary 2017" . Therapeutic Goods Administration (TGA) . 21 June 2022. Retrieved 31 March 2024 .
^ "Search Page - Drug and Health Product Register" . 23 October 2014.
^ "Health Canada New Drug Authorizations: 2016 Highlights" . Health Canada . Retrieved 7 April 2024 .
^ "Adynovi EPAR" . European Medicines Agency . 8 January 2018. Retrieved 20 June 2024 .
^ "Advate EPAR" . European Medicines Agency . 2 March 2004. Retrieved 20 June 2024 .
^ a b c d World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008 . World Health Organization. pp. 259–60. hdl :10665/44053 ISBN 9789241547659
^ a b c d e British National Formulary : BNF 69 . British Medical Association. 2015. p. 171. ISBN 978-0857111562
^ a b "Alphanate – Summary of Product Characteristics (SPC) – (eMC)" . www.medicines.org.uk . Archived from the original on 9 January 2017. Retrieved 8 January 2017 .
^ Potts DM (2011). "Chapter 5" . Queen Victoria's Gene: Haemophilia and the Royal Family . The History Press. ISBN 978-0752471969 Archived from the original on 9 January 2017.
^ High KA (2012). "In vivo characteristics of rDNA Factor VIII: The impact for the future in hemophilia care" . In Sibinga CS, Das PC, Overby LR (eds.). Biotechnology in blood transfusion: Proceedings of the Twelfth Annual Symposium on Blood Transfusion, Groningen 1987, organized by the Red Cross Blood Bank Groningen-Drenthe . Springer Science & Business Media. p. 224. doi :10.1007/978-1-4613-1761-6_19 . ISBN 978-1461317616 Archived from the original on 9 January 2017.
^ Brownlee GG, Giangrande PL (2012). "Clotting factors VIII and IX" . In Buckel P (ed.). Recombinant Protein Drugs . Birkhäuser. p. 79. ISBN 978-3034883467 Archived from the original on 9 January 2017.
^ Zimring JC, Duncan A (2006). "Chapter 25 - Coagulation Factor Preparations" . In Hillyer CD (ed.). Blood Banking and Transfusion Medicine: Basic Principles & Practice . Elsevier Health Sciences. p. 353. doi :10.1016/B978-0-443-06981-9.50030-2 . ISBN 0443069816 Archived from the original on 9 January 2017.
^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019 . Geneva: World Health Organization. hdl :10665/325771
^ a b Nathwani AC, Davidoff AM, Tuddenham EG (October 2017). "Gene Therapy for Hemophilia". Hematology/Oncology Clinics of North America . 31 5 ): 853–868. doi :10.1016/j.hoc.2017.06.011 . PMID 28895852 . S2CID 3779939 .
^ a b Machin N, Ragni MV, Smith KJ (July 2018). "Gene therapy in hemophilia A: a cost-effectiveness analysis" . Blood Advances . 2 14 ): 1792–1798. doi :10.1182/bloodadvances.2018021345 . PMC 6058236 PMID 30042145 .
External links
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R e t r i e v e d f r o m " https://en.wikipedia.org/w/index.php?title=Factor_VIII_(medication)&oldid=1230034139 " C a t e g o r i e s : ● D r u g s n o t a s s i g n e d a n A T C c o d e ● A n t i h e m o r r h a g i c s ● D r u g s d e v e l o p e d b y B a y e r ● D r u g s d e v e l o p e d b y T a k e d a P h a r m a c e u t i c a l C o m p a n y ● W o r l d H e a l t h O r g a n i z a t i o n e s s e n t i a l m e d i c i n e s H i d d e n c a t e g o r i e s : ● A r t i c l e s w i t h s h o r t d e s c r i p t i o n ● S h o r t d e s c r i p t i o n m a t c h e s W i k i d a t a ● U s e d m y d a t e s f r o m M a r c h 2 0 2 4 ● D r u g s w i t h n o n - s t a n d a r d l e g a l s t a t u s ● C h e m i c a l s t h a t d o n o t h a v e a C h e m S p i d e r I D a s s i g n e d ● I n f o b o x d r u g a r t i c l e s w i t h n o n - d e f a u l t i n f o b o x t i t l e ● C h e m i c a l a r t i c l e s w i t h o u t C A S r e g i s t r y n u m b e r ● A r t i c l e s w i t h o u t E B I s o u r c e ● C h e m i c a l p a g e s w i t h o u t D r u g B a n k i d e n t i f i e r ● A r t i c l e s w i t h o u t K E G G s o u r c e ● A r t i c l e s w i t h o u t I n C h I s o u r c e ● A r t i c l e s w i t h o u t U N I I s o u r c e ● A r t i c l e s c o n t a i n i n g u n v e r i f i e d c h e m i c a l i n f o b o x e s ● I n f o b o x d r u g a r t i c l e s w i t h o u t a s t r u c t u r e i m a g e ● C h e m i c a l p a g e s w i t h o u t C h e m S p i d e r I D ● A l l a r t i c l e s w i t h u n s o u r c e d s t a t e m e n t s ● A r t i c l e s w i t h u n s o u r c e d s t a t e m e n t s f r o m D e c e m b e r 2 0 2 1 ● W i k i p e d i a m e d i c i n e a r t i c l e s r e a d y t o t r a n s l a t e
● T h i s p a g e w a s l a s t e d i t e d o n 2 0 J u n e 2 0 2 4 , a t 0 5 : 5 3 ( U T C ) . ● T e x t i s a v a i l a b l e u n d e r t h e C r e a t i v e C o m m o n s A t t r i b u t i o n - S h a r e A l i k e L i c e n s e 4 . 0 ;
a d d i t i o n a l t e r m s m a y a p p l y . B y u s i n g t h i s s i t e , y o u a g r e e t o t h e T e r m s o f U s e a n d P r i v a c y P o l i c y . W i k i p e d i a ® i s a r e g i s t e r e d t r a d e m a r k o f t h e W i k i m e d i a F o u n d a t i o n , I n c . , a n o n - p r o f i t o r g a n i z a t i o n . ● P r i v a c y p o l i c y ● A b o u t W i k i p e d i a ● D i s c l a i m e r s ● C o n t a c t W i k i p e d i a ● C o d e o f C o n d u c t ● D e v e l o p e r s ● S t a t i s t i c s ● C o o k i e s t a t e m e n t ● M o b i l e v i e w
