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Contents

   



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1 References  













Fenpiverinium






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From Wikipedia, the free encyclopedia
  

Fenpiverinium
Clinical data
ATC code
Identifiers

  • 1-(4-Amino-4-oxo-3,3-diphenylbutyl)-1-methylpiperidinium

CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC22H29N2O+
Molar mass337.487 g·mol−1
3D model (JSmol)

  • C[N+]1(CCCCC1)CCC(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N

  • InChI=1S/C22H28N2O/c1-24(16-9-4-10-17-24)18-15-22(21(23)25,19-11-5-2-6-12-19)20-13-7-3-8-14-20/h2-3,5-8,11-14H,4,9-10,15-18H2,1H3,(H-,23,25)/p+1

  • Key:QDIYJDPBMZUZEH-UHFFFAOYSA-O

  (verify)

Fenpiverinium is an anticholinergic and antispasmodic compound;[1] it is marketed as a combination drug with pitofenone hydrochloride and either nimesulideormetamizole in Eastern Europe and India to treat smooth muscle spasms and pain.[2]

The combination with metamizole was removed from the market in Lithuania for safety reasons in 2000[3] and a boxed warning against use by children and adolescents was added in Serbia in 2005.[4] In 2016 India banned marketing of the combination with nimesulide along with 344 other combination drugs;[5][6] the order was overturned in December and appealed by the Government in January 2017.[7]

References[edit]

  1. ^ "Proposed INNs List 26" (PDF). WHO Chronicle. 25 (9). 1971.. "Recommended INNs List 12" (PDF). WHO Chronicle. 26 (10). 1973.
  • ^ Vardanyan R (2017). Piperidine-Based Drug Discovery. Elsevier. ISBN 9780128134283.
  • ^ Consolidated List of Products - Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or Not Approved by Governments, Twelfth Issue. WHO. 2005. p. 305. Archived from the original on November 8, 2014.
  • ^ Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or not Approved by Governments, Fourteenth Issue. WHO. 2009. p. 35.[dead link]
  • ^ "Health ministry bans 344 fixed dose combination drugs". The Times of India. March 14, 2016.
  • ^ "Gazette of India D. L.-33004/99. PART II—Section 3—Sub-section (ii)" (PDF). Government of India. March 10, 2016. Archived from the original (PDF) on 2018-08-26. Retrieved 2017-06-22.
  • ^ "Govt moves SC to enforce ban on 344 Fixed Dose Combination drugs". The Times of India. January 31, 2017.


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